AC T04236
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ID T04236
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DT 25.01.2001 (created); dkl.
DT 22.08.2012 (updated); pos.
CO Copyright (C), QIAGEN.
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FA Smad6
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SY Smad-6.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002371 Smad6.
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CL C0041; SMAD; 7.1.1.3.1.
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CP (adult): heart, brain, lung, liver, skeletal muscle, kidney [1].
CN (adult): spleen [1].
EX brain,,,adult; detectable; Northern blot; RNA (undefined); [1].
EX heart,,,adult; detectable; Northern blot; RNA (undefined); [1].
EX kidney (right and left),,,adult; detectable; Northern blot; RNA (undefined); [1].
EX liver,,,adult; detectable; Northern blot; RNA (undefined); [1].
EX lung,,,adult; detectable; Northern blot; RNA (undefined); [1].
EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [1].
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FF Smad6 inhibits activin A-induced phosphorylation of Smad2;
FF activin A and Smad6 enhance cell cycle arrest in the G1-phase [3];
FF Smad6 is an important antagonist preferentially for the BMP (bone morphogenetic proteins) signaling pathway [7];
FF corepressor [7];
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IN T01710 hoxa9; mouse, Mus musculus.
IN T01749 HOXC-8; mouse, Mus musculus.
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MX M08897 V$SMAD_Q4.
MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000019072.
DR UniProtKB: O35182; O35182.
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RN [1]; RE0015642.
RX PUBMED: 9335505.
RA Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K.
RT Smad6 inhibits signalling by the TGF-beta superfamily
RL Nature 389:622-626 (1997).
RN [2]; RE0016188.
RX PUBMED: 10376010.
RA Christian J. L., Nakayama T.
RT Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.
RL BioEssays 21:382-390 (1999).
RN [3]; RE0020663.
RX PUBMED: 10224135.
RA Ishisaki A., Yamato K., Hashimoto S., Nakao A., Tamaki K., Nonaka K., ten Dijke P., Sugino H., Nishihara T.
RT Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
RL J. Biol. Chem. 274:13637-13642 (1999).
RN [4]; RE0021582.
RX PUBMED: 10748100.
RA Kimura N., Matsuo R., Shibuya H., Nakashima K., Taga T.
RT BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
RL J. Biol. Chem. 275:17647-17652 (2000).
RN [5]; RE0049823.
RX PUBMED: 16951688.
RA Choi K. C., Lee Y. S., Lim S., Choi H. K., Lee C. H., Lee E. K., Hong S., Kim I. H., Kim S. J., Park S. H.
RT Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.
RL Nat. Immunol. 7:1057-1065 (2006).
RN [6]; RE0066522.
RX PUBMED: 17493607.
RA Simirskii V. N., Wang Y., Duncan M. K.
RT Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.
RL Dev. Biol. 306:658-668 (2007).
RN [7]; RE0047353.
RX PUBMED: 10722652.
RA Bai S., Shi X., Yang X., Cao X.
RT Smad6 as a transcriptional corepressor.
RL J. Biol. Chem. 275:8267-8270 (2000).
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