AC T01749
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ID T01749
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DT 20.03.1996 (created); ewi.
DT 23.06.2015 (updated); msr.
CO Copyright (C), QIAGEN.
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FA HOXC-8
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SY D130011F21Rik; homeo box C8; Hox-3.1; Hoxc-8; HOXC8; m31.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001732 Hoxc8.
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HO abd-A (Drosophila).
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CL C0006; homeo; 3.1.1.7.2.
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SF binds with relatively low affinity to a canonical homeo domain binding site (KD = 8 nM) [1];
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CP (embryo 8.5 days:) allantois, segmental plate mesoderm, anterior neurectoderm, (embryo 9.5 days:) neural tube, paraxial mesoderm, lateral plate mesoderm, (embryo >9.5 days:) posterior decreased and anterior increased expression [12].
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FF transcriptional repressor [15];
FF transcriptional repressor but the interaction with SMAD1 dislodges HOXC-8 binding from its response element resulting in initiation of gene transcription [16];
FF specifies some thoracic and lumbar skeletal segments;
FF null mutants have the 8th pair of ribs attached to the sternum, possess a 14th pair of ribs on the first lumbar vertebra [4];
FF may exert negative control on the beta-amyloid gene [5];
FF in 8-9.5d embryos, a 5-kb fragment of HOXC-8 gene is sufficient to mediate the expression pattern [3];
FF later (10.5 days and later), additional 2 kb are required for negative control [3];
FF also expressed in certain kidney substructures [14] [13];
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IN T04254 Smad1; mouse, Mus musculus.
IN T05067 Smad4; mouse, Mus musculus.
IN T04236 Smad6; mouse, Mus musculus.
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MX M01321 V$HOXC8_01.
MX M07421 V$HOXC8_Q3.
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BS R68482.
BS R68484.
BS R68486.
BS R68487.
BS R68490.
BS R68492.
BS R68493.
BS R61414.
BS R61415.
BS R61416.
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DR TRANSPATH: MO000046061.
DR UniProtKB: P09025; HXC8_MOUSE.
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RN [1]; RE0003885.
RX PUBMED: 7911971.
RA Pellerin I., Schnabel C., Catron K. M., Abate C.
RT Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
RL Mol. Cell. Biol. 14:4532-4545 (1994).
RN [2]; RE0004000.
RX PUBMED: 1696731.
RA Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F. H.
RT Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region
RL Proc. Natl. Acad. Sci. USA 87:6428-6432 (1990).
RN [3]; RE0004001.
RX PUBMED: 1978325.
RA Bieberich C., Utset M. F., Awgulewitsch A., Ruddle F. H.
RT Evidence for positive and negative regulation of the Hox-3.1 gene
RL Proc. Natl. Acad. Sci. USA 87:8462-8466 (1990).
RN [4]; RE0004002.
RX PUBMED: 1348969.
RA Le Mouellic H., Lallemand Y., Brulet P.
RT Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene
RL Cell 69:251-264 (1992).
RN [5]; RE0004003.
RX PUBMED: 1349171.
RA Violette S. M., Shashikant C. S., Salbaum J. M., Belting H.-G., Wang J. C. H., Ruddle F. H.
RT Repression of the beta-amyloid gene in a Hox-3.1-producing cell line
RL Proc. Natl. Acad. Sci. USA 89:3805-3809 (1992).
RN [6]; RE0004004.
RX PUBMED: 1360875.
RA Pollock R. A., Jay G., Bieberich C. J.
RT Altering the boundaries of Hox3.1 expression: evidence for antipodal gene regulation
RL Cell 71:911-923 (1992).
RN [7]; RE0004005.
RX PUBMED: 8103190.
RA Tomotsune D., Shoji H., Wakamatsu Y., Kondoh H., Takahashi N.
RT A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo
RL Nature 365:69-72 (1993).
RN [8]; RE0004007.
RX PUBMED: 3007994.
RA Awgulewitsch A., Utset M. F., Hart C. P., McGinnis W., Ruddle F. H.
RT Spatial restriction in expression of a mouse homeo box locus within the central nervous system
RL Nature 320:328-335 (1986).
RN [9]; RE0004008.
RX PUBMED: 2900757.
RA Breier G., Dressler G. R., Gruss P.
RT Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster
RL EMBO J. 7:1329-1336 (1988).
RN [10]; RE0004009.
RX PUBMED: 2895723.
RA Mouellic H. L., Condamine H., Brulet P.
RT Pattern of transcription of the homeo gene Hox 3.1 in the mouse embryo
RL Genes Dev. 2:125-135 (1988).
RN [11]; RE0004010.
RX PUBMED: 1353983.
RA Peterson R. L., Jacobs D. F., Awgulewitsch A.
RT Hox 3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox 3 cluster
RL Mech. Dev. 37:151-166 (1992).
RN [12]; RE0006406.
RX PUBMED: 8901587.
RA Shashikant C. S., Ruddle F. H.
RT Combinations of closely situated cis-acting elements determine tissue-specific patterns and anterior extent if early Hoxc8 expression
RL Proc. Natl. Acad. Sci. USA 93:12364-12369 (1996).
RN [13]; RE0006757.
RX PUBMED: 2904354.
RA Gaunt S. J.
RT Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5
RL Development 103:135-144 (1988).
RN [14]; RE0014517.
RA Davies J. A., Brandli A. W.
RT The Kidney Development Database; URL: http://www.ana.ed.ac.uk/anatomy/database/kidbase/tranfack.html
RL Internet : (1997).
RN [15]; RE0035672.
RX PUBMED: 15699330.
RA Lei H., Wang H., Juan A. H., Ruddle F. H.
RT The identification of Hoxc8 target genes.
RL Proc. Natl. Acad. Sci. USA 102:2420-2424 (2005).
RN [16]; RE0047352.
RX PUBMED: 10224145.
RA Shi X., Yang X., Chen D., Chang Z., Cao X.
RT Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling.
RL J. Biol. Chem. 274:13711-13717 (1999).
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