AC T01496
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ID T01496
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DT 06.06.1995 (created); ewi.
DT 13.12.2006 (updated); kau.
CO Copyright (C), QIAGEN.
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FA HTF4alpha
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SY ALF1; ALF1B; GE1 (chick); HEB; HTF-4; HTF4; ME1; ME1a; REB; SCBPalpha (rat); TCF12; transcription factor 12.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001147 Tcf12.
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CL C0010; bHLH.
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SZ 706 AA; 75.8 kDa (cDNA) (calc.).
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SQ MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSW
SQ GTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLY
SQ SRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDSVALDPLQA
SQ KKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSS
SQ SNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRG
SQ STSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNP
SQ STPVGSPSPLTGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCE
SQ QSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNASIGNLNSNYGGSSL
SQ VTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPENFRGGVQNQSGSVVPT
SQ EIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREK
SQ ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRE
SQ RNLNPKAACLKRREEEKVSAASAEPPSTLPGAHPGLSESTNPMGHL
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SC conceptually translated from EMBL/GenBank/DDBJ #X64840
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FT 72 638 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 600 655 
PS50888; HLH.
FT 602 655 
PF00010; Helix-loop-helix DNA-binding domain.
FT 607 660 
SM00353; finulus.
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SF a shorter splice variant is ALF1A which corresponds to murine HEB;
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CP high levels in ovary, thymus, low in brain, kidney, lung [2].
CN heart, spleen, stomach [2].
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IN T09198 Id3; mouse, Mus musculus.
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MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M00698 V$HEB_Q6.
MX M02018 V$HTF4_Q2.
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BS R04249.
BS R04410.
BS R04411.
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DR TRANSPATH: MO000025710.
DR EMBL: X64840;
DR UniProtKB: Q61286-1;
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RN [1]; RE0003069.
RX PUBMED: 1321336.
RA Nielsen A. L., Pallisgaard N., Pedersen F. S., Jorgensen P.
RT Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning
RL Mol. Cell. Biol. 12:3449- 3459 (1992).
RN [2]; RE0003087.
RX PUBMED: 1312219.
RA Hu J.-S., Olson E. N., Kingston R. E.
RT HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
RL Mol. Cell. Biol. 12:1031-1042 (1992).
RN [3]; RE0003731.
RX PUBMED: 7784173.
RA Shain D. H., Neuman T., Zuber M. X.
RT A novel initiator regulates expression of the nontissue-specific helix-loop-helix gene ME1
RL Nucleic Acids Res. 23:1696-1703 (1995).
RN [4]; RE0003751.
RX PUBMED: 8261111.
RA Neuman T., Keen A., Knapik E., Shain D., Ross M., Nornes H. O., Zuber M. X.
RT ME1 and GE1: Basic helix-loop-helix expressed at high levels in the developing nervous system and in morphogenetically active regions
RL Eur. J. Neurosci. 5:311-318 (1993).
RN [5]; RE0012509.
RX PUBMED: 8759016.
RA Loveys D. A., Streiff M. B., Kato G. J.
RT E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the ld3 protein
RL Nucleic Acids Res. 24:2813-2820 (1996).
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