AC T01547
XX
ID T01547
XX
DT 07.08.1995 (created); ewi.
CO Copyright (C), QIAGEN.
XX
FA E2F
XX
SY dE2F.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G002031 E2f1.
XX
HO E2F-1, E2F-2, E2F-3.
XX
CL C0023; fork head.
XX
SZ 805 AA; 87.4 kDa (cDNA) (calc.).
XX
SQ MSKFFVNVAPINNSNSSSSHTTTSSNTQRHQQHQQHYGGSGTTGHTMVARRLNYDLHGGT
SQ TSINNNNNIVIKNESVDLDYDHVLSSSDSNSNGGVAAHLRDHVYISLDKGHNTGAVATAA
SQ AAATAGQTQQQLQQQHHHQNQQQRKATGKSNDITNYYKVKRRPHAVSDEIHPKKQAKQSA
SQ HHQTVYQKHTASSAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHHPFSLSTPQQQLA
SQ ASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNV
SQ LEGINILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEI
SQ SQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVLPNTKLPREIYVKAENSGE
SQ INVFLCHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMST
SQ KGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQQQLLQQPEE
SQ DDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSLTESSPPTPTKRRREAAAAAIA
SQ AGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQPPTIGYGSSQRRSDVPMYNCAME
SQ GATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGGGGGGGYGSIAGAGANAD
SQ PHQPYSHDRNSLPPGVADCDANSNSSSVTLQGLDALFNDIGSDYFSNDIAFVSINPPDDN
SQ DYPYALNANEGIDRLFDFGSDAYGP
XX
SC translated from EMBL #X78421
XX
FT 76 539 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 225 432 
required for interaction with dDP [1].
FT 254 319 
PF02319; E2F/DP family winged-helix DNA-binding domai.
XX
SF no recognizable basic region;
SF larger size compared with mammalian E2F-factors is due to a large insertion between the zipper and the Rb-binding region;
SF strictly requires heterodimerization with dDP for DNA-binding;
SF prior to crystal structure belongs to bHLH-zip factors [3];
XX
FF heterodimeric complex with dDP: transcriptional activator;
FF DREF T04324 activates transcription of E2F [4];
XX
IN T01550 DP; fruit fly, Drosophila melanogaster.
XX
BS R09605.
BS R09606.
BS R09607.
XX
DR TRANSPATH: MO000025754.
DR EMBL: X78421;
DR UniProtKB: Q27368;
DR FLYBASE: FBgn0011766; E2f.
XX
RN [1]; RE0003320.
RX PUBMED: 8022787.
RA Dynlacht B. D., Brook A., Dembski M., Yenush L., Dyson N.
RT DNA-binding and trans-activation by Drosophila E2F and DP proteins
RL Proc. Natl. Acad. Sci. USA 91:6359-6363 (1994).
RN [2]; RE0008756.
RX PUBMED: 8114698.
RA Ohtani K., Nevins J. R.
RT Functional properties of a Drosophila homolog of the E2F1 gene
RL Mol. Cell. Biol. 14:1603-1612 (1994).
RN [3]; RE0015322.
RX PUBMED: 10090723.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P.
RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP
RL Genes Dev. 13:666-674 (1999).
RN [4]; RE0016902.
RX PUBMED: 9748283.
RA Sawado T., Hirose F., Takahashi Y., Sasaki T., Shinomiya T., Sakaguchi K., Matsukage A., Yamaguchi M.
RT The DNA replication-related element (DRE)/DRE-binding factor system is a transcriptional regulator of the Drosophila E2F gene
RL J. Biol. Chem. 273:26042-26051 (1998).
XX
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