AC T01555
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ID T01555
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DT 14.09.1995 (created); ewi.
DT 06.05.2015 (updated); mka.
CO Copyright (C), QIAGEN.
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FA USF2
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SY FIP; Fos-interacting protein; upstream stimulatory factor 2; USF II; USF44.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006863 Usf2.
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CL C0012; bHLH-ZIP; 1.2.6.2.2.
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SF detection of endogenous USF2 in IEC lines (intestinal epithelial cell, such as CaCo2, HT-29, LS174T and m-ICc12) [6];
SF immunologically unrelated to USF1 [1];
SF there are splice variants and variants from alternative translation initiation and polyadenylation [1];
SF similar DNA-binding affinity as USF1 (KD = 0.93 nM) [1];
SF both the USR and the basic region act as independent nuclear localization signals [2];
SF there are also two independent trans-activation domains [2];
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CP ubiquitous (brain, heart, kidney, liver, lung, muscle, spleen, testis) [1]; brain, testis, liver [4].
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FF transcriptional activator [2];
FF antiproliferative effect, inhibits transformation by c-Myc and E1a [3];
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IN T00877 usf1; mouse, Mus musculus.
IN T02378 usf1; Kenyan clawed frog, Xenopus borealis.
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MX M01034 V$EBOX_Q6_01.
MX M07067 V$USF1_Q4.
MX M00726 V$USF2_Q6.
MX M03860 V$USF2_Q6_01.
MX M00187 V$USF_Q6.
MX M00796 V$USF_Q6_01.
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BS R18513.
BS R18514.
BS R18515.
BS R18516.
BS R18517.
BS R29713.
BS R22523.
BS R22524.
BS R20949.
BS R57290.
BS R57299.
BS R21551.
BS R33150.
BS R18512.
BS R18593.
BS R26752.
BS R21767.
BS R56452.
BS R41532.
BS R21548.
BS R24211.
BS R16585.
BS R67491.
BS R67498.
BS R08129.
BS R25621.
BS R18594.
BS R39007.
BS R24788.
BS R14618.
BS R29511.
BS R60181.
BS R34288.
BS R39027.
BS R19438.
BS R71483.
BS R26755.
BS R28684.
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DR TRANSPATH: MO000025760.
DR TRANSCOMPEL: C00600.
DR UniProtKB: Q64705; USF2_MOUSE.
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RN [1]; RE0003427.
RX PUBMED: 8127680.
RA Sirito M., Lin Q., Maity T., Sawadogo M.
RT Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells
RL Nucleic Acids Res. 22:427-433 (1994).
RN [2]; RE0006750.
RX PUBMED: 8657110.
RA Luo X., Sawadogo M.
RT Functional domains of the transcription factor USF2: Atypical nuclear localization signals and context-dependent transcriptional activation domains
RL Mol. Cell. Biol. 16:1367-1375 (1996).
RN [3]; RE0006751.
RX PUBMED: 8577760.
RA Luo X., Sawadogo M.
RT Antiproliferative properties of the USF family of helix-loop-helix transcription factors
RL Proc. Natl. Acad. Sci. USA 93:1308-1313 (1996).
RN [4]; RE0046855.
RX PUBMED: 11058604.
RA Kumari D., Usdin K.
RT Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome
RL J. Biol. Chem. 276:4357-64 (2001).
RN [5]; RE0047940.
RX PUBMED: 15014447.
RA Giangrande P. H., Zhu W., Rempel R. E., Laakso N., Nevins J. R.
RT Combinatorial gene control involving E2F and E Box family members.
RL EMBO J. 23:1336-1347 (2004).
RN [6]; RE0032905.
RX PUBMED: 14644095.
RA Bruno M. E., West R. B., Schneeman T. A., Bresnick E. H., Kaetzel C. S.
RT Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene.
RL Mol. Immunol. 40:695-708 (2004).
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