AC T01557
XX
ID T01557
XX
DT 14.09.1995 (created); ewi.
DT 20.02.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA SREBP-1b
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003956 SREBF1; HGNC: SREBF1.
XX
CL C0012; bHLH-ZIP; 1.2.6.3.1.2.
XX
SZ 1071 AA; 113.5 kDa (cDNA) (calc.).
XX
SQ MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPPYAGSGAGGTD
SQ PASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGP
SQ GIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGN
SQ TQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLL
SQ QPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDA
SQ EKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKS
SQ AVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTE
SQ VEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSR
SQ GMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGW
SQ AQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQ
SQ AAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRV
SQ DASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYV
SQ AAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVL
SQ STPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYL
SQ QLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPL
SQ VEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTP
SQ ASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGASSRPQASALELRGFQRDLSS
SQ LRRLAQSFRPAMRRLMDVLTSESAWALPQHLGKGFPSPSGHKVPGWHGRMD
XX
SC translated from EMBL #U00968 and #S66168 and edited
XX
FT 1 29 
replaced by 1-5 in SREBP-1c [3].
FT 3 413 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 322 374 
PS50888; HLH.
FT 324 374 
PF00010; Helix-loop-helix DNA-binding domain.
FT 329 379 
SM00353; finulus.
FT 1035 1071 
replaced by 1035-1147 in SREBP-1a [3].
XX
SF one of the three splice variants, for others see SREBP-1a T01556 and SREBP-1c T01558;
SF bHLH domain exhibits 44% identity with TFE3 [2];
SF in cell extracts, N-terminal proteolytically processed proteins of 59-68 kDa are found to bind to sterol regulatory elements [1] [4];
SF the mature factor then translocates to the nucleus [4];
XX
CP adult: high in liver, adrenal gland, lower in muscle, kidney, placenta, very low in lung, nearly undetectable in pancreas, brain, heart; fetal: highest levels in liver, lung, lower in kidney, very low in heart, brain [2].
XX
FF transcriptional activator, acting through sterol regulatory elements (SRE) [3];
FF sterols may reduce or enhance trans-activation, depending on the amount of SREBP-1 (or cofactors) present [3];
FF SREBP-1 precursors are attached to the nuclear envelope and to the ER [4];
XX
MX M00220 V$SREBP1_01.
MX M00221 V$SREBP1_02.
MX M01173 V$SREBP1_Q5.
MX M00749 V$SREBP1_Q6.
MX M04632 V$SREBP1_Q6_01.
MX M00776 V$SREBP_Q3.
MX M01168 V$SREBP_Q6.
XX
BS R28157.
BS R04919.
BS R04920.
XX
DR TRANSPATH: MO000025762.
DR EMBL: S66167;
DR EMBL: S66168;
DR EMBL: U00968;
DR UniProtKB: P36956-2;
XX
RN [1]; RE0003430.
RX PUBMED: 8314806.
RA Wang X., Briggs M. R., Hua X., Yokoyama C., Goldstein J. L., Brown M. S.
RT Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter (2. Purification and characterization)
RL J. Biol. Chem. 268:14497-14504 (1993).
RN [2]; RE0003432.
RX PUBMED: 2298751.
RA Smith J. R., Osborne T. F., Goldstein J. L., Brown M. S.
RT Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor genes
RL J. Biol. Chem. 265:2306-2310 (1990).
RN [3]; RE0003434.
RX PUBMED: 8402897.
RA Yokoyama C., Wang X., Briggs M. R., Admon A., Wu J., Hua X., Goldstein J., Brown M. S.
RT SREBP-1, a basic helix-loop-helix leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
RL Cell 75:187-197 (1993).
RN [4]; RE0003435.
RX PUBMED: 8156598.
RA Wang X., Sato R. R., Brown M. S., Hua X., Goldstein J. L.
RT SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
RL Cell 77:53-62 (1994).
XX
//