AC T01702
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ID T01702
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DT 06.03.1996 (created); ewi.
DT 19.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA HOXA5
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SY HOX1C.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013855 HOXA5; HGNC: HOXA5.
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HO Scr (Drosophila).
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CL C0006; homeo.
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SZ 270 AA; 29.4 kDa (cDNA) (calc.).
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SQ MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSG
SQ SGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDTHHGGKN
SQ SLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWM
SQ RKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIK
SQ IWFQNRRMKWKKDNKLKSMSMAAAGGAFRP
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SC Swiss-Prot#P20719
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FT 81 105 
necessary and sufficient for interaction with Twist T04913 [5].
FT 193 253 
PS50071; HOMEOBOX_2.
FT 195 257 
SM00389; HOX_1.
FT 196 252 
PF00046; Homeobox domain.
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CP (embryo 11 weeks:) fetal brain [4].
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FF inducible by retinoic acid (RA), the response to RA is counteracted by N-ras [1];
FF also expressed in certain kidney substructures [3];
FF may safeguard p53 response (to gamma-radiation) by virtue of its direct interaction with Twist T04913 [5];
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IN T04913 TWIST; human, Homo sapiens.
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MX M00023 V$HOX13_01.
MX M01452 V$HOX13_02.
MX M02271 V$HOXA5_03.
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BS R15446.
BS R15498.
BS R15443.
BS R15445.
BS R15447.
BS R15448.
BS R15452.
BS R22794.
BS R15706.
BS R66340.
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DR TRANSPATH: MO000025881.
DR EMBL: M26679;
DR UniProtKB: P20719;
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RN [1]; RE0003855.
RX PUBMED: 1675427.
RA Buettner R., Yim S. O., Hong Y. S., Boncinelli E., Tainsky M. A.
RT Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells
RL Mol. Cell. Biol. 11:3573-3583 (1991).
RN [2]; RE0003881.
RX PUBMED: 2568583.
RA Tournier-Lasserve E., Odenwald W. F., Garbern J., Trojanowski J., Lazzarini R. A.
RT Remarkable intron and exon sequence conservation in human and mouse homeobox hox 1.3 genes
RL Mol. Cell. Biol. 9:2273-2278 (1989).
RN [3]; RE0014517.
RA Davies J. A., Brandli A. W.
RT The Kidney Development Database; URL: http://www.ana.ed.ac.uk/anatomy/database/kidbase/tranfack.html
RL Internet : (1997).
RN [4]; RE0015345.
RX PUBMED: 8838315.
RA Lin X., Swaroop A., Vaccarino F. M., Murtha M. T., Haas M., Ji X., Ruddle F. H., Leckman J. F.
RT Characterization and sequence analysis of the human homeobox-containing gene GBX2
RL Genomics 31:335-342 (1996).
RN [5]; RE0035184.
RX PUBMED: 15545268.
RA Stasinopoulos I. A., Mironchik Y., Raman A., Wildes F., Winnard P J. r., Raman V.
RT HOXA5-twist interaction alters p53 homeostasis in breast cancer cells.
RL J. Biol. Chem. 280:2294-2299 (2005).
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