AC T04913
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ID T04913
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DT 26.11.2001 (created); rge.
DT 03.03.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA TWIST
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SY h-twist; TWIST1; TWISTrelated protein.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006856 TWIST1; HGNC: TWIST1.
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CL C0010; bHLH; 1.2.3.2.1.
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FF Inducible by EGF in MDA-MB-468, A431, PANC-28, CHO-EGFR, Her5/NR-6-EGFR [7];
FF plays a role in rhabdomyosarcomas [5];
FF compromises the p53 response to gamma-radiation [6];
FF may interfere with p53 Ser20 phosphorylation [6];
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IN T00207 E47; human, Homo sapiens.
IN T01702 HOXA5; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
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MX M03582 V$TWIST_Q6.
MX M07435 V$TWIST_Q6_01.
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BS R39404.
BS R63899.
BS R28289.
BS R72935.
BS R63627.
BS R16617.
BS R72239.
BS R71634.
BS R71635.
BS R62886.
BS R72937.
BS R72079.
BS R72089.
BS R38807.
BS R38808.
BS R38809.
BS R38811.
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DR TRANSPATH: MO000028695.
DR UniProtKB: Q15672;
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RN [1]; RE0017235.
RX PUBMED: 8995765.
RA Bourgeois P., Stoetzel C., Bolcato-Bellemin A. L., Mattei M. G., Perrin-Schmitt F.
RT The human H-twist gene is located at 7p21 and encodes a B-HLH protein that is 96% similar to its murine M-twist counterpart
RL Mamm. Genome 7:915-917 (1996).
RN [2]; RE0017236.
RX PUBMED: 8988166.
RA Howard T. D., Paznekas W. A., Green E. D., Chiang L. C., Ma N., Ortiz de Luna R. I., Garcia Delgado C., Gonzalez-Ramos M., Kline A. D., Jabs E. W.
RT Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome
RL Nat. Genet. 15:36-41 (1997).
RN [3]; RE0017237.
RX PUBMED: 9215678.
RA Krebs I., Weis I., Hudler M., Rommens J. M., Roth H., Scherer S. W., Tsui L. C., Fuchtbauer E. M., Grzeschik K. H., Tsuji K., Kunz J.
RT Translocation breakpoint maps 5 kb 3' from TWIST in a patient affected with Saethre-Chotzen syndrome
RL Hum. Mol. Genet. 6:1079-1086 (1997).
RN [4]; RE0017238.
RX PUBMED: 8988167.
RA el Ghouzzi V., Le Merrer M., Perrin-Schmitt F., Lajeunie E., Benit P., Renier D., Bourgeois P., Bolcato-Bellemin A. L., Munnich A., Bonaventure J.
RT Mutations of the TWIST gene in the Saethre-Chotzen syndrome
RL Nat. Genet. 15:42-46 (1997).
RN [5]; RE0035102.
RX PUBMED: 11948912.
RA Villavicencio E. H., Yoon J. W., Frank D. J., Fuchtbauer E. M., Walterhouse D. O., Iannaccone P. M.
RT Cooperative E-box regulation of human GLI1 by TWIST and USF.
RL Genesis 32:247-258 (2002).
RN [6]; RE0035184.
RX PUBMED: 15545268.
RA Stasinopoulos I. A., Mironchik Y., Raman A., Wildes F., Winnard P J. r., Raman V.
RT HOXA5-twist interaction alters p53 homeostasis in breast cancer cells.
RL J. Biol. Chem. 280:2294-2299 (2005).
RN [7]; RE0053305.
RX PUBMED: 17909010.
RA Lo H. W., Hsu S. C., Xia W., Cao X., Shih J. Y., Wei Y., Abbruzzese J. L., Hortobagyi G. N., Hung M. C.
RT Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
RL Cancer Res. 67:9066-9076 (2007).
RN [8]; RE0065788.
RX PUBMED: 19198599.
RA Kajiro M., Hirota R., Nakajima Y., Kawanowa K., So-ma K., Ito I., Yamaguchi Y., Ohie S. H., Kobayashi Y., Seino Y., Kawano M., Kawabe Y., Takei H., Hayashi S., Kurosumi M., Murayama A., Kimura K., Yanagisawa J.
RT The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
RL Nat. Cell Biol. 11:312-319 (2009).
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