AC T01851
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ID T01851
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DT 12.06.1996 (created); dbo.
DT 22.06.2009 (updated); ada.
CO Copyright (C), QIAGEN.
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FA HMGIY-isoform1
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SY high mobility group protein I; High Mobility Group protein I(Y); HMG I(Y); HMG-I(Y); HMGA1; HMGA1a; HMGIY; MGC12816; MGC4242; MGC4854.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004779 HMGA1; HGNC: HMGA1.
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CL C0083; AT-hook; 8.2.1.0.1.1.
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SZ 106 AA; 11.5 kDa (cDNA) (calc.), 20 kDa (SDS) [6]
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SQ SESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRP
SQ KGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ
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SC Swiss-Prot#P17096-1
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FT 22 34 
PF02178; AT_hook.
FT 22 34 
SM00384; AT_hook.
FT 54 66 
PF02178; AT_hook.
FT 54 66 
SM00384; AT_hook.
FT 80 92 
PF02178; AT_hook.
FT 80 92 
SM00384; AT_hook.
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SF alternative splice product is HMG Y T01980 [2];
SF no HMG box present;
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FF auxiliary to other transcription factors [4] [7];
FF recognizes base-unpairing regions [6];
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MX M01010 V$HMGIY_Q3.
MX M07320 V$HMGIY_Q3_01.
MX M01879 V$HMGIY_Q4.
MX M00750 V$HMGIY_Q6.
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BS R21570.
BS R21573.
BS R21576.
BS R13015.
BS R74080.
BS R03340.
BS R00920.
BS R04663.
BS R14811.
BS R00935.
BS R21567.
BS R73938.
BS R14740.
BS R14743.
BS R05081.
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DR TRANSPATH: MO000006707.
DR TRANSCOMPEL: C00057.
DR TRANSCOMPEL: C00118.
DR TRANSCOMPEL: C00140.
DR TRANSCOMPEL: C00146.
DR TRANSCOMPEL: C00167.
DR TRANSCOMPEL: C00344.
DR TRANSCOMPEL: C00345.
DR TRANSCOMPEL: C00418.
DR TRANSCOMPEL: C00419.
DR EMBL: L17131;
DR EMBL: M23614;
DR EMBL: M23619;
DR EMBL: X14957;
DR UniProtKB: P17096-1;
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RN [1]; RE0004350.
RX PUBMED: 2505228.
RA Eckner R., Birnstiel M. L.
RT Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif
RL Nucleic Acids Res. 17:5947-5959 (1989).
RN [2]; RE0004351.
RX PUBMED: 2701943.
RA Johnson K. R., Lehn D. A., Reeves R.
RT Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y
RL Mol. Cell. Biol. 9:2114-2123 (1989).
RN [3]; RE0004352.
RX PUBMED: 8414980.
RA Friedmann M., Holth L. T., Zoghbi H. Y., Reeves R.
RT Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene
RL Nucleic Acids Res. 21:4259-4267 (1993).
RN [4]; RE0004376.
RX PUBMED: 1330326.
RA Thanos D., Maniatis T.
RT The high mobility group protein HMG I(Y) is required for NF-kappaB-dependent virus induction of the human IFN-beta gene
RL Cell 71:777-789 (1992).
RN [5]; RE0004378.
RX PUBMED: 8407950.
RA Reeves R., Nissen M. S.
RT Interaction of high-mobility-group-I (Y) nonhistone proteins with nucleosome core particles
RL J. Biol. Chem. 268:21137-21146 (1993).
RN [6]; RE0014852.
RX PUBMED: 10582687.
RA Liu W.-M., Guerra-Vladusic F. K., Kurakata S., Lupu R., Kohwi-Shigematsu T.
RT HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype
RL Cancer Res. 59:5695-5703 (1999).
RN [7]; RE0016568.
RX PUBMED: 8374955.
RA Du W., Thanos D., Maniatis T.
RT Mechanism of transcriptional synergism between distinct virus-inducible enhancer elements.
RL Cell 74:887-898 (1993).
RN [8]; RE0019849.
RX PUBMED: 3619901.
RA LUND T., DAHL K.H., MORK E., HOLTLUND J., LALAND S.G.
RT The human chromosomal protein HMG I contains two identical palindrome amino acid sequences.
RL Biochem. Biophys. Res. Commun. 146:725-730 (1987).
RN [9]; RE0019857.
RX PUBMED: 1692833.
RA REEVES R., NISSEN M.S.
RT The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.
RL J. Biol. Chem. 265:8573-8582 (1990).
RN [10]; RE0055553.
RX PUBMED: 17960875.
RA Zhang Q., Wang Y.
RT Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.
RL J. Proteome Res. 6:4711-4719 (2007).
RN [11]; RE0055566.
RX PUBMED: 17627840.
RA Zhang Q., Zhang K., Zou Y., Perna A., Wang Y.
RT A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins.
RL J. Am. Soc. Mass Spectrom. 18:1569-1578 (2007).
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