TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01851 XX ID T01851 XX DT 12.06.1996 (created); dbo. DT 22.06.2009 (updated); ada. CO Copyright (C), QIAGEN. XX FA HMGIY-isoform1 XX SY high mobility group protein I; High Mobility Group protein I(Y); HMG I(Y); HMG-I(Y); HMGA1; HMGA1a; HMGIY; MGC12816; MGC4242; MGC4854. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004779 HMGA1; HGNC: HMGA1. XX CL C0083; AT-hook; XX SZ 106 AA; 11.5 kDa (cDNA) (calc.), 20 kDa (SDS) [6] XX SQ SESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRP SQ KGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ XX SC Swiss-Prot#P17096-1 XX FT 22 34 PF02178; AT_hook. FT 22 34 SM00384; AT_hook. FT 54 66 PF02178; AT_hook. FT 54 66 SM00384; AT_hook. FT 80 92 PF02178; AT_hook. FT 80 92 SM00384; AT_hook. XX SF alternative splice product is HMG Y T01980 [2]; SF no HMG box present; XX FF auxiliary to other transcription factors [4] [7]; FF recognizes base-unpairing regions [6]; XX MX M01010 V$HMGIY_Q3. MX M07320 V$HMGIY_Q3_01. MX M01879 V$HMGIY_Q4. MX M00750 V$HMGIY_Q6. XX BS R21570. BS R21573. BS R21576. BS R13015. BS R74080. BS R03340. BS R00920. BS R04663. BS R14811. BS R00935. BS R21567. BS R73938. BS R14740. BS R14743. BS R05081. XX DR TRANSPATH: MO000006707. DR TRANSCOMPEL: C00057. DR TRANSCOMPEL: C00118. DR TRANSCOMPEL: C00140. DR TRANSCOMPEL: C00146. DR TRANSCOMPEL: C00167. DR TRANSCOMPEL: C00344. DR TRANSCOMPEL: C00345. DR TRANSCOMPEL: C00418. DR TRANSCOMPEL: C00419. DR EMBL: L17131; DR EMBL: M23614; DR EMBL: M23619; DR EMBL: X14957; DR UniProtKB: P17096-1; XX RN [1]; RE0004350. RX PUBMED: 2505228. RA Eckner R., Birnstiel M. L. RT Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif RL Nucleic Acids Res. 17:5947-5959 (1989). RN [2]; RE0004351. RX PUBMED: 2701943. RA Johnson K. R., Lehn D. A., Reeves R. RT Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y RL Mol. Cell. Biol. 9:2114-2123 (1989). RN [3]; RE0004352. RX PUBMED: 8414980. RA Friedmann M., Holth L. T., Zoghbi H. Y., Reeves R. RT Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene RL Nucleic Acids Res. 21:4259-4267 (1993). RN [4]; RE0004376. RX PUBMED: 1330326. RA Thanos D., Maniatis T. RT The high mobility group protein HMG I(Y) is required for NF-kappaB-dependent virus induction of the human IFN-beta gene RL Cell 71:777-789 (1992). RN [5]; RE0004378. RX PUBMED: 8407950. RA Reeves R., Nissen M. S. RT Interaction of high-mobility-group-I (Y) nonhistone proteins with nucleosome core particles RL J. Biol. Chem. 268:21137-21146 (1993). RN [6]; RE0014852. RX PUBMED: 10582687. RA Liu W.-M., Guerra-Vladusic F. K., Kurakata S., Lupu R., Kohwi-Shigematsu T. RT HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype RL Cancer Res. 59:5695-5703 (1999). RN [7]; RE0016568. RX PUBMED: 8374955. RA Du W., Thanos D., Maniatis T. RT Mechanism of transcriptional synergism between distinct virus-inducible enhancer elements. RL Cell 74:887-898 (1993). RN [8]; RE0019849. RX PUBMED: 3619901. RA LUND T., DAHL K.H., MORK E., HOLTLUND J., LALAND S.G. RT The human chromosomal protein HMG I contains two identical palindrome amino acid sequences. RL Biochem. Biophys. Res. Commun. 146:725-730 (1987). RN [9]; RE0019857. RX PUBMED: 1692833. RA REEVES R., NISSEN M.S. RT The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. RL J. Biol. Chem. 265:8573-8582 (1990). RN [10]; RE0055553. RX PUBMED: 17960875. RA Zhang Q., Wang Y. RT Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. RL J. Proteome Res. 6:4711-4719 (2007). RN [11]; RE0055566. RX PUBMED: 17627840. RA Zhang Q., Zhang K., Zou Y., Perna A., Wang Y. RT A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins. RL J. Am. Soc. Mass Spectrom. 18:1569-1578 (2007). XX //