TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01980 XX ID T01980 XX DT 29.11.1996 (created); ewi. DT 06.03.2012 (updated); mkl. CO Copyright (C), QIAGEN. XX FA HMGIY-isoform2 XX SY high mobility group AT-hook 1; high mobility group protein Y; HMG I(Y); HMG-R; HMG-Y; HMGA1b; HMGIY; MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004779 HMGA1; HGNC: HMGA1. XX CL C0083; AT-hook; XX SZ 96 AA; 10.7 kDa (cDNA) (calc.). XX SQ MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPKEPSEVPTPKRPRGRPKGSKNKGAAK SQ TRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ XX SC Swiss-Prot#P17096-2 XX FT 22 34 PF02178; AT_hook. FT 22 34 SM00384; AT_hook. FT 43 55 PF02178; AT_hook. FT 43 55 SM00384; AT_hook. FT 69 81 PF02178; AT_hook. FT 69 81 SM00384; AT_hook. XX SF alternative splice product is HMG I T01851 [2]; SF no HMG box present; XX FF auxiliary to other transcription factors [4] [7]; FF recognizes base-unpairing regions [6]; XX IN T00167 ATF-2-isoform1; human, Homo sapiens. XX MX M01010 V$HMGIY_Q3. MX M07320 V$HMGIY_Q3_01. MX M01879 V$HMGIY_Q4. MX M00750 V$HMGIY_Q6. XX BS R13015. BS R34517. BS R04663. XX DR TRANSPATH: MO000006710. DR EMBL: L17131; HSHMGIY. DR EMBL: M23615; DR EMBL: M23616; DR EMBL: M23617; DR EMBL: M23618; DR EMBL: X14958; DR UniProtKB: P17096-2; DR PDB: 2EZD. DR PDB: 2EZE. DR PDB: 2EZF. DR PDB: 2EZG. XX RN [1]; RE0004350. RX PUBMED: 2505228. RA Eckner R., Birnstiel M. L. RT Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif RL Nucleic Acids Res. 17:5947-5959 (1989). RN [2]; RE0004351. RX PUBMED: 2701943. RA Johnson K. R., Lehn D. A., Reeves R. RT Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y RL Mol. Cell. Biol. 9:2114-2123 (1989). RN [3]; RE0004352. RX PUBMED: 8414980. RA Friedmann M., Holth L. T., Zoghbi H. Y., Reeves R. RT Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene RL Nucleic Acids Res. 21:4259-4267 (1993). RN [4]; RE0004376. RX PUBMED: 1330326. RA Thanos D., Maniatis T. RT The high mobility group protein HMG I(Y) is required for NF-kappaB-dependent virus induction of the human IFN-beta gene RL Cell 71:777-789 (1992). RN [5]; RE0004378. RX PUBMED: 8407950. RA Reeves R., Nissen M. S. RT Interaction of high-mobility-group-I (Y) nonhistone proteins with nucleosome core particles RL J. Biol. Chem. 268:21137-21146 (1993). RN [6]; RE0014852. RX PUBMED: 10582687. RA Liu W.-M., Guerra-Vladusic F. K., Kurakata S., Lupu R., Kohwi-Shigematsu T. RT HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype RL Cancer Res. 59:5695-5703 (1999). RN [7]; RE0016568. RX PUBMED: 8374955. RA Du W., Thanos D., Maniatis T. RT Mechanism of transcriptional synergism between distinct virus-inducible enhancer elements. RL Cell 74:887-898 (1993). RN [8]; RE0019850. RX PUBMED: 9253416. RA HUTH J.R., BEWLEY C.A., NISSEN M.S., EVANS J.N., REEVES R., GRONENBORN A.M., CLORE G.M. RT The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif. RL Nat. Struct. Biol. 4:657-665 (1997). RN [9]; RE0019851. RX PUBMED: 2920035. RA KARLSON J.R., MORK E., HOLTLUND J., LALAND S.G., LUND T. RT The amino acid sequence of the chromosomal protein HMG-Y, its relation to HMG-I and possible domains for the preferential binding of the proteins to stretches of A-T base pairs. RL Biochem. Biophys. Res. Commun. 158:646-651 (1989). RN [10]; RE0019857. RX PUBMED: 1692833. RA REEVES R., NISSEN M.S. RT The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. RL J. Biol. Chem. 265:8573-8582 (1990). RN [11]; RE0055553. RX PUBMED: 17960875. RA Zhang Q., Wang Y. RT Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. RL J. Proteome Res. 6:4711-4719 (2007). RN [12]; RE0055566. RX PUBMED: 17627840. RA Zhang Q., Zhang K., Zou Y., Perna A., Wang Y. RT A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins. RL J. Am. Soc. Mass Spectrom. 18:1569-1578 (2007). XX //