AC T01980
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ID T01980
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DT 29.11.1996 (created); ewi.
DT 06.03.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA HMGIY-isoform2
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SY high mobility group AT-hook 1; high mobility group protein Y; HMG I(Y); HMG-R; HMG-Y; HMGA1b; HMGIY; MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004779 HMGA1; HGNC: HMGA1.
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CL C0083; AT-hook; 8.2.1.0.1.2.
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SZ 96 AA; 10.7 kDa (cDNA) (calc.).
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SQ MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPKEPSEVPTPKRPRGRPKGSKNKGAAK
SQ TRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ
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SC Swiss-Prot#P17096-2
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FT 22 34 
PF02178; AT_hook.
FT 22 34 
SM00384; AT_hook.
FT 43 55 
PF02178; AT_hook.
FT 43 55 
SM00384; AT_hook.
FT 69 81 
PF02178; AT_hook.
FT 69 81 
SM00384; AT_hook.
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SF alternative splice product is HMG I T01851 [2];
SF no HMG box present;
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FF auxiliary to other transcription factors [4] [7];
FF recognizes base-unpairing regions [6];
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IN T00167 ATF-2-isoform1; human, Homo sapiens.
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MX M01010 V$HMGIY_Q3.
MX M07320 V$HMGIY_Q3_01.
MX M01879 V$HMGIY_Q4.
MX M00750 V$HMGIY_Q6.
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BS R13015.
BS R34517.
BS R04663.
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DR TRANSPATH: MO000006710.
DR EMBL: L17131; HSHMGIY.
DR EMBL: M23615;
DR EMBL: M23616;
DR EMBL: M23617;
DR EMBL: M23618;
DR EMBL: X14958;
DR UniProtKB: P17096-2;
DR PDB: 2EZD.
DR PDB: 2EZE.
DR PDB: 2EZF.
DR PDB: 2EZG.
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RN [1]; RE0004350.
RX PUBMED: 2505228.
RA Eckner R., Birnstiel M. L.
RT Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif
RL Nucleic Acids Res. 17:5947-5959 (1989).
RN [2]; RE0004351.
RX PUBMED: 2701943.
RA Johnson K. R., Lehn D. A., Reeves R.
RT Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y
RL Mol. Cell. Biol. 9:2114-2123 (1989).
RN [3]; RE0004352.
RX PUBMED: 8414980.
RA Friedmann M., Holth L. T., Zoghbi H. Y., Reeves R.
RT Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene
RL Nucleic Acids Res. 21:4259-4267 (1993).
RN [4]; RE0004376.
RX PUBMED: 1330326.
RA Thanos D., Maniatis T.
RT The high mobility group protein HMG I(Y) is required for NF-kappaB-dependent virus induction of the human IFN-beta gene
RL Cell 71:777-789 (1992).
RN [5]; RE0004378.
RX PUBMED: 8407950.
RA Reeves R., Nissen M. S.
RT Interaction of high-mobility-group-I (Y) nonhistone proteins with nucleosome core particles
RL J. Biol. Chem. 268:21137-21146 (1993).
RN [6]; RE0014852.
RX PUBMED: 10582687.
RA Liu W.-M., Guerra-Vladusic F. K., Kurakata S., Lupu R., Kohwi-Shigematsu T.
RT HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype
RL Cancer Res. 59:5695-5703 (1999).
RN [7]; RE0016568.
RX PUBMED: 8374955.
RA Du W., Thanos D., Maniatis T.
RT Mechanism of transcriptional synergism between distinct virus-inducible enhancer elements.
RL Cell 74:887-898 (1993).
RN [8]; RE0019850.
RX PUBMED: 9253416.
RA HUTH J.R., BEWLEY C.A., NISSEN M.S., EVANS J.N., REEVES R., GRONENBORN A.M., CLORE G.M.
RT The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.
RL Nat. Struct. Biol. 4:657-665 (1997).
RN [9]; RE0019851.
RX PUBMED: 2920035.
RA KARLSON J.R., MORK E., HOLTLUND J., LALAND S.G., LUND T.
RT The amino acid sequence of the chromosomal protein HMG-Y, its relation to HMG-I and possible domains for the preferential binding of the proteins to stretches of A-T base pairs.
RL Biochem. Biophys. Res. Commun. 158:646-651 (1989).
RN [10]; RE0019857.
RX PUBMED: 1692833.
RA REEVES R., NISSEN M.S.
RT The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.
RL J. Biol. Chem. 265:8573-8582 (1990).
RN [11]; RE0055553.
RX PUBMED: 17960875.
RA Zhang Q., Wang Y.
RT Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.
RL J. Proteome Res. 6:4711-4719 (2007).
RN [12]; RE0055566.
RX PUBMED: 17627840.
RA Zhang Q., Zhang K., Zou Y., Perna A., Wang Y.
RT A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins.
RL J. Am. Soc. Mass Spectrom. 18:1569-1578 (2007).
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