AC T01880
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ID T01880
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DT 08.08.1996 (created); ewi.
DT 19.02.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Brn-3b
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SY Brn-3.2; Brn-3b; Brn3.2; Brn3b; POU4F2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002464 POU4F2; HGNC: POU4F2.
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HO unc-86 T01882 (C. elegans).
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CL C0007; POU; 3.1.10.4.2.
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SF high homology with Brn-3a within POU domain (91.8%), but very little similarity outside [2];
SF component of the neuroretina-specific protein complex within the DF4 site of the EP enhancer of Pax-6 [3];
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CP (embryo day 7:) neuroretina cells [3].
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FF repressor, due to differences in the POU domain when compared with the activator Brn-3a [1];
FF strongly activates the EP enhancer of Pax-6 in neuroretina cells but no other cell types [3];
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MX M05357 V$BRN3B_01.
MX M07036 V$BRN3B_Q2.
MX M04086 V$POU4F2_01.
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BS R08616.
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DR TRANSPATH: MO000026000.
DR UniProtKB: Q12837;
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RN [1]; RE0004225.
RX PUBMED: 7935408.
RA Morris P. J., Theil T., Ring C. J. A., Lillycrop K. A., Moroy T., Latchman D. S.
RT The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in POU domain
RL Mol. Cell. Biol. 14:6907-6914 (1994).
RN [2]; RE0004414.
RX PUBMED: 8332509.
RA Ring C. J. A., Latchman D. S.
RT The human Brn-3b POU transcription factor shows only limited homology to the Br-3a/RDC-1 factor outside the conserved POU domain
RL Nucleic Acids Res. 21:2946-2946 (1993).
RN [3]; RE0014055.
RX PUBMED: 10526314.
RA Plaza S., Hennemann H., Moroy T., Saule S., Dozier C.
RT Evidence that POU factor Brn-3b regulates expression of Pax-6 in neuroretina cells
RL J. Neurobiol. 41:349-358 (1999).
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