AC T02003
XX
ID T02003
XX
DT 13.12.1996 (created); ewi.
DT 07.11.2011 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Cdx-3
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SY Cdx-2; shCdx-2.
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OS golden (Syrian) hamster, Mesocricetus auratus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; cricetidae; cricetinae; cricetini
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HO Cad (Drosophila), Cdx-3.
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CL C0006; homeo; 3.1.1.9.2.
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SF similar DNA-binding specificity as Lmx-1 [1];
SF Cdx-3 is the hamster homologue of Cdx-3 [2] [3];
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CP intestine, pancreas islets, low levels in testis [1]; cell lines (INR1-G9 and HIT cells) [2] [2] [1].
CN brain, liver, exocrine cells of pancreas [1]; cell lines (BHK cells) [2] [2] [1].
XX
FF activator of the insulin and glucagon gene [2] [1];
FF probably involved in the post-weaning decline of lactase-phlorizin hydrolase (LPH) causing lactose intolerance [3];
FF Cdx-3/3 mediates activation of the proglucagon promoter in both islet and enteroendocrine cells [2];
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IN T09257 pax-6; quail, Coturnix coturnix.
IN T08770 PDX-1; Mammalia.
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MX M00729 V$CDX2_Q5.
MX M01659 V$CDX2_Q5_01.
MX M02087 V$CDX2_Q5_02.
MX M07416 V$CDX2_Q6.
MX M07378 V$CDX_Q4.
MX M00991 V$CDX_Q5.
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BS R14653.
BS R08848.
BS R36407.
BS R70533.
XX
DR TRANSPATH: MO000045995.
DR TRANSCOMPEL: C00280.
DR TRANSCOMPEL: C00579.
DR UniProtKB: Q04649; CDX3_MESAU.
XX
RN [1]; RE0004765.
RX PUBMED: 1358758.
RA German M. S., Wang J., Chadwick R. B., Rutter W. J.
RT Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex
RL Genes Dev. 6:2165-2176 (1992).
RN [2]; RE0011831.
RX PUBMED: 8524295.
RA Jin T., Drucker D. J.
RT Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3
RL Mol. Cell. Biol. 16:19-28 (1996).
RN [3]; RE0014403.
RX PUBMED: 9148757.
RA Troelsen J. T., Mitchelmore C., Spodsberg N., Jensen A. M., Noren O., Sjoestroem H.
RT Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2
RL Biochem. J. 322:833-838 (1997).
XX
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