AC T02009
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ID T02009
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DT 16.12.1996 (created); ewi.
DT 11.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Dlx-2
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SY distalless homeobox 2; Dlx-2; Tes-1; Tes1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002015 Dlx2.
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HO Dll (Drosophila) T02005.
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CL C0006; homeo; 3.1.2.5.2.
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SF closely linked to the Dlx-1 T02006 gene within a 25 kb genomic region [5];
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CP CNS (ventral forebrain exclusively), teeth (ameloblasts) [1] [2]; anlagen of the embryonic striatum [6]; medial and lateral ganglionic eminences [6]; retinal neuroepithelium [6] [6] [1] [2].
CN heart, kidney, liver, lung, skin, spleen, stomach, testis, adult brain [1] [2].
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FF may play a role in the development of forebrain structures [1] [2];
FF expression in telencephalon is prenatally shut off [2];
FF for expression in teeth, see also [4];
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MX M01468 V$DLX2_01.
MX M04311 V$DLX2_04.
MX M08873 V$DLX2_Q6.
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BS R32539.
BS R16172.
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DR TRANSPATH: MO000026089.
DR UniProtKB: P40764;
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RN [1]; RE0005026.
RX PUBMED: 1687503.
RA Robinson G. W., Wray S., Mahon K. A.
RT Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain
RL New Biol. 3:1183-1194 (1991).
RN [2]; RE0005027.
RX PUBMED: 1678612.
RA Porteus M. H., Bulfone A., Ciaranello R. D., Rubenstein J. L.
RT Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentaly regulated in the ventral forebrain
RL Neuron 7:221-229 (1991).
RN [3]; RE0006801.
RX PUBMED: 8812481.
RA McGuinness T., Porteus M. H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J., Long J. E., Czernik A., Xu D., Rubenstein J. L. R.
RT Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus
RL Genomics 35:473-485 (1996).
RN [4]; RE0014816.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/DLX2.htm
RL Internet : (1996).
RN [5]; RE0015261.
RX PUBMED: 7907794.
RA Simeone A., Acampora D., Pannese M., D'Esposito M., Stornaiuolo A., Gulisano M., Mallamaci A., Kastury K., Druck T., Huebner K., Bonicinelli E.
RT Cloning and characterization of two members of the vertebrate Dlx gene family
RL Proc. Natl. Acad. Sci. USA 91:2250-2254 (1994).
RN [6]; RE0035085.
RX PUBMED: 14769946.
RA Zhou Q. P., Le T. N., Qiu X., Spencer V., de Melo J., Du G., Plews M., Fonseca M., Sun J. M., Davie J. R., Eisenstat D. D.
RT Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation.
RL Nucleic Acids Res. 32:884-892 (2004).
RN [7]; RE0052163.
RX PUBMED: 16707790.
RA Kuwajima T., Nishimura I., Yoshikawa K.
RT Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins.
RL J. Neurosci. 26:5383-5392 (2006).
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