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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T02009 XX ID T02009 XX DT 16.12.1996 (created); ewi. DT 11.01.2016 (updated); mkl. CO Copyright (C), QIAGEN. XX FA Dlx-2 XX SY distalless homeobox 2; Dlx-2; Tes-1; Tes1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002015 Dlx2. XX HO Dll (Drosophila) T02005. XX CL C0006; homeo; 3.1.2.5.2. XX SF closely linked to the Dlx-1 T02006 gene within a 25 kb genomic region [5]; XX CP CNS (ventral forebrain exclusively), teeth (ameloblasts) [1] [2]; anlagen of the embryonic striatum [6]; medial and lateral ganglionic eminences [6]; retinal neuroepithelium [6] [6] [1] [2]. CN heart, kidney, liver, lung, skin, spleen, stomach, testis, adult brain [1] [2]. XX FF may play a role in the development of forebrain structures [1] [2]; FF expression in telencephalon is prenatally shut off [2]; FF for expression in teeth, see also [4]; XX MX M01468 V$DLX2_01. MX M04311 V$DLX2_04. MX M08873 V$DLX2_Q6. XX BS R32539. BS R16172. XX DR TRANSPATH: MO000026089. DR UniProtKB: P40764; XX RN [1]; RE0005026. RX PUBMED: 1687503. RA Robinson G. W., Wray S., Mahon K. A. RT Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain RL New Biol. 3:1183-1194 (1991). RN [2]; RE0005027. RX PUBMED: 1678612. RA Porteus M. H., Bulfone A., Ciaranello R. D., Rubenstein J. L. RT Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentaly regulated in the ventral forebrain RL Neuron 7:221-229 (1991). RN [3]; RE0006801. RX PUBMED: 8812481. RA McGuinness T., Porteus M. H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J., Long J. E., Czernik A., Xu D., Rubenstein J. L. R. RT Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus RL Genomics 35:473-485 (1996). RN [4]; RE0014816. RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I. RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/DLX2.htm RL Internet : (1996). RN [5]; RE0015261. RX PUBMED: 7907794. RA Simeone A., Acampora D., Pannese M., D'Esposito M., Stornaiuolo A., Gulisano M., Mallamaci A., Kastury K., Druck T., Huebner K., Bonicinelli E. RT Cloning and characterization of two members of the vertebrate Dlx gene family RL Proc. Natl. Acad. Sci. USA 91:2250-2254 (1994). RN [6]; RE0035085. RX PUBMED: 14769946. RA Zhou Q. P., Le T. N., Qiu X., Spencer V., de Melo J., Du G., Plews M., Fonseca M., Sun J. M., Davie J. R., Eisenstat D. D. RT Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation. RL Nucleic Acids Res. 32:884-892 (2004). RN [7]; RE0052163. RX PUBMED: 16707790. RA Kuwajima T., Nishimura I., Yoshikawa K. RT Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. RL J. Neurosci. 26:5383-5392 (2006). XX //