TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02020 XX ID T02020 XX DT 16.12.1996 (created); ewi. DT 04.09.2008 (updated); tgo. CO Copyright (C), QIAGEN. XX FA En-2 XX SY Engrailed 2; Gg-en.2 (chick); Hu-en.2 (human); Mo-en.2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001723 En2. XX HO En (Drosophila) T00253. XX CL C0006; homeo; XX SF tightly linked to Gbx-1 T04024 [7]; XX CP cerebellum (embryo, adult) [2]. CN frontal cortex (embryo, adult), liver, lung (embryo) [2]. EX junction between mesencephalon and rhombencephalon,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [8]. EX neural tube,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [8]. XX FF may be involved in the regulation of the development of parts of the CNS [4]; FF required for normal development of cerebellum; FF different expression pattern than En-1, but may replace En-1 when placed under control of En-1 promoter [3]; FF expression in the neural plate (embryonal) is induced by FGF-8 [5]; FF Pax-2, Pax-5 and Pax-8 show overlapping expression with the engrailed genes and bind as activators to the En-2 5' enhancer [6]; XX MX M01455 V$EN2_01. XX DR TRANSPATH: MO000026100. DR UniProtKB: P09066; XX RN [1]; RE0005044. RX PUBMED: 2892757. RA Joyner A. L., Martin G. R. RT En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis RL Genes Dev. 1:29-38 (1987). RN [2]; RE0005045. RX PUBMED: 1363401. RA Logan C., Hanks M. C., Noble-Topham S., Nallainathan D., Provart N. J., Joyner A. L. RT Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions RL Dev. Genet. 13:345-358 (1992). RN [3]; RE0005048. RX PUBMED: 7624797. RA Hanks M., Wurst W., Anson-Cartwright L., Auerbach A. B., Joyner A. L. RT Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2 RL Science 269:679-682 (1995). RN [4]; RE0005052. RX PUBMED: 2563902. RA Joyner A. L., Skarnes W. C., Rossant J. RT Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells RL Nature 338:153-156 (1989). RN [5]; RE0006703. RX PUBMED: 8598907. RA Crossley P. H., Martinez S., Martin G. R. RT Midbrain development induced by FGF8 in the chick embryo RL Nature 380:66-68 (1996). RN [6]; RE0014313. RX PUBMED: 8625814. RA Song D. L., Chalepakis G., Gruss P., Joyner A. L. RT Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene RL Development 122:627-635 (1996). RN [7]; RE0015359. RA Frohman M. A., Dickinson M. E., Hogan B. L. M., Martin G. R. RT Mapping of Gbx-1 to mouse chromosome 5 and Gbx-2 to mouse chromosome 1 RL Mouse Genome 91:323-325 (1993). RN [8]; RE0015599. RX PUBMED: 9022063. RA Sheng H. Z., Bertuzzi S., Chiang C., Shawlot W., Taira M., Dawid I., Westphal H. RT Expression of murine Lhx5 suggests a role in specifying the forebrain RL Dev. Dyn. 208:266-277 (1997). XX //