AC T02054
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ID T02054
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DT 28.01.1997 (created); ewi.
DT 27.01.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA HOX11
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SY Tcl-3; Tlx-1 (mouse).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002689 TLX1; HGNC: TLX1.
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CL C0006; homeo; 3.1.2.21.1.
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SF belongs to the distinct homeobox gene family, together with HOX11L1 and HOX11L2 [5];
SF unusual Thr residue within homeo domain recognition helix instead of Ile/Val [5];
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CP childhood T acute lymphoblastic leukemias (T-ALL) [6].
CN normal adult tissues: thymus, bone marrow [6].
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FF gene is activated after either chromosomal translocation t(10;
FF 14)(q24;
FF q11) (to the T-cell receptor delta, TCRD, locus) or t(7;
FF 10)(q35;
FF q24) (to the TCR-beta, TCRB locus) [1] [4];
FF resulting ectopic HOX11 expression may cause T-cell tumorigenesis [1];
FF is expressed in about 10 percent of T-ALL samples [6];
FF belongs to the group of T-cell oncogenes encoding for transcription factors: HOX11, HOX11L1, HOX11L2, TAL1, LYL1, LMO2 [6];
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IN T00176 CTF-1; human, Homo sapiens.
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DR TRANSPATH: MO000026125.
DR UniProtKB: P31314;
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RN [1]; RE0005113.
RX PUBMED: 1681546.
RA Kennedy M. A., Gonzalez-Sarmiento R., Kees U. R., Lampert F., Dear N., Boehm T., Rabbitts T. H.
RT HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24
RL Proc. Natl. Acad. Sci. USA 88:8900-8904 (1991).
RN [2]; RE0005114.
RX PUBMED: 1717256.
RA Gong Z., Shen W., Lu M., Ho A.
RT The tcl-3 proto-oncogene altered by chromosomal translocation in T-cellleukemia codes for a homeobox protein
RL EMBO J. 10:2905-2910 (1991).
RN [3]; RE0005116.
RX PUBMED: 1352396.
RA Lu M., Zhang N., Ho A. D.
RT Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells
RL Oncogene 7:1325-1330 (1992).
RN [4]; RE0005117.
RX PUBMED: 1676542.
RA Hatano M., Roberts C. W., Minden M., Crist W. M., Korsmeyer S. J.
RT Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia
RL Science 253:79-82 (1991).
RN [5]; RE0005118.
RX PUBMED: 8099440.
RA Dear T. N., Sanchez-Garcia I., Rabbitts T. H.
RT The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes
RL Proc. Natl. Acad. Sci. USA 90:4431-4435 (1993).
RN [6]; RE0023849.
RX PUBMED: 12130513.
RA Ballerini P., Blaise A., Busson-Le Coniat M., Su X. Y., Zucman-Rossi J., Adam M., van den Akker J., Perot C., Pellegrino B., Landman-Parker J., Douay L., Berger R., Bernard O. A.
RT HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.
RL Blood 100:991-997 (2002).
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