AC T02055
XX
ID T02055
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DT 28.01.1997 (created); ewi.
DT 18.10.2004 (updated); oke.
CO Copyright (C), QIAGEN.
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FA Hox11
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SY Tcl-3 (human); Tlx-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002690 Tlx1.
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CL C0006; homeo.
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SZ 332 AA; 34.6 kDa (cDNA) (calc.).
XX
SQ MEHLGPHHLHPGHAEPISFGIEQILNSPDQGGCMGPNSRLQDGDYGLGCLVPGAYTYGGG
SQ GSAAGAGAGGTGAYGAGGPGGPGGPAGGGGGACSMGPLPGSYNVNMDLAGGPGPGGDGGG
SQ GGAARRALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAVPGVNNLTGLTFPWME
SQ SNRRYTKDRFTGLPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKAL
SQ KMTDAQVKTWFQNRRTKWRRQTAEEREAESEQANRILLQLQQEAFQKSLAQPLPADPLCV
SQ HNSSLFALQNLQPWSDDSTKITSVTSVASACE
XX
SC Swiss-Prot#P43345
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FT 201 261 
PS50071; HOMEOBOX_2.
FT 203 265 
SM00389; HOX_1.
FT 204 260 
PF00046; Homeobox domain.
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SF sequence and length conflict: 332 AA versus 284 AA [3] [4];
SF unusual Thr residue within homeo domain recognition helix instead of Ile/Val [3];
SF gene located on chromosome 19 [5];
SF same optimal binding sequence as Ncx T04368 [7];
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CP for expression in teeth, see [6]; neurons in developing hindbrain and spinal cord [8]; [6] [8].
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FF activator [3];
FF specifically required for spleen development [2];
FF together with TLX3/Rnx/HOX11L2, is associated with development of somatic sensory neurons and D2/D4 dorsal interneurons [8];
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BS R04970.
BS R11090.
BS R11091.
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DR TRANSPATH: MO000026126.
DR EMBL: L21164;
DR EMBL: L21165;
DR EMBL: L21166;
DR EMBL: L21167;
DR EMBL: L21168;
DR EMBL: L21169;
DR EMBL: S70629;
DR EMBL: S70632;
DR EMBL: S70756;
DR UniProtKB: P43345;
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RN [1]; RE0005113.
RX PUBMED: 1681546.
RA Kennedy M. A., Gonzalez-Sarmiento R., Kees U. R., Lampert F., Dear N., Boehm T., Rabbitts T. H.
RT HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24
RL Proc. Natl. Acad. Sci. USA 88:8900-8904 (1991).
RN [2]; RE0005115.
RX PUBMED: 7908720.
RA Roberts C. W. M., Shutter J. R., Korsmeyer S. J.
RT Hox11 controls the genesis of the spleen
RL Nature 368:747-749 (1994).
RN [3]; RE0005118.
RX PUBMED: 8099440.
RA Dear T. N., Sanchez-Garcia I., Rabbitts T. H.
RT The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes
RL Proc. Natl. Acad. Sci. USA 90:4431-4435 (1993).
RN [4]; RE0005374.
RX PUBMED: 7908826.
RA Raju K., Tang S., Dube I. D., Kamel-Reid S., Bryce D. M., Breitman M. L.
RT Characterization and developmental expression of Tlx-1, the murine homolog of HOX11
RL Mech. Dev. 44:51-64 (1993).
RN [5]; RE0006755.
RX PUBMED: 7698766.
RA Wen X. Y., Tang S., Breitman M. L.
RT Genetic mapping of two mouse homebox genes Tlx-1 and Tlx-2 to murine chromosomes 19 and 6
RL Genomics 24:388-390 (1994).
RN [6]; RE0014817.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/TLX1.htm
RL Internet : (1996).
RN [7]; RE0016874.
RX PUBMED: 10869550.
RA Shimizu H., Kang M., Iitsuka Y., Ichinose M., Tokuhisa T., Hatano M.
RT Identification of an optimal Ncx binding sequence required for transcriptional activation
RL FEBS Lett. 475:170-174 (2000).
RN [8]; RE0023846.
RX PUBMED: 12023301.
RA Qian Y., Shirasawa S., Chen C. L., Cheng L., Ma Q.
RT Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.
RL Genes Dev. 16:1220-1233 (2002).
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