AC T04368
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ID T04368
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DT 02.03.2001 (created); rio.
DT 12.08.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Ncx
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SY enteric neuron homeobox; Enx; HOX11 like 1; HOX11L1; Tlx2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002304 Tlx2.
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CL C0006; homeo; 3.1.2.21.2.
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SF same optimal binding sequence as Hox11 T02055 [4];
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CP (cell lines:) C1300, B16, M12 [1].
CN (cell lines:) B16, L fibroblasts, M12B [1].
EX distal colon,,,Theiler Stage 28; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX distal ileum,,,Theiler Stage 28; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX dorsal root ganglion,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX geniculate ganglion of facial nerve [VII],,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX glossopharyngeal ganglion [IX],,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX myenteric plexus,,,Theiler Stage 28; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX parasympathetic ganglia of the heart,,,Theiler Stage 21; medium; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX paravertebral ganglia,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX proximal colon,,,Theiler Stage 28; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX small intestine,,,Theiler Stage 28; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX submucous plexus,,,Theiler Stage 28; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX trigeminal ganglion [V],,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX vagal ganglion [x],,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
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FF activator [4];
FF required for proper positional specification, differentiative cell fate and maintenance of proper function of enteric neurons [2] [3];
FF Ncx -/- mice exhibit distended abdomens (megacolon), myenteric neuronal hyperplasia, altered NADPH diaphorase inhibitory neurons in colon ganglia, hyperinnervated enteric neurons, retarded growth after weaning and die between 3-6 weeks [2] [3];
FF Ncx -/- mice provide a model for human neuronal intestinal dysplasia (NID) [2];
FF expression is upregulated after retinoic acid stimulation probably due to a potential retinoic acid response element (RARE) in the promoter [1];
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MX M00484 V$NCX_01.
MX M01420 V$NCX_02.
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DR TRANSPATH: MO000028225.
DR UniProtKB: Q61663;
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RN [1]; RE0015841.
RX PUBMED: 10446220.
RA Iitsuka Y., Shimizu H., Kang M. M., Sasagawa K., Sekiya S., Tokuhisa T., Hatano M.
RT An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells
RL J. Biol. Chem. 274:24401-24407 (1999).
RN [2]; RE0015860.
RX PUBMED: 9176491.
RA Shirasawa S., Yunker A. M., Roth K. A., Brown G. A., Horning S., Korsmeyer S. J.
RT Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon
RL Nat. Med. 3:646-650 (1997).
RN [3]; RE0015863.
RX PUBMED: 9259577.
RA Hatano M., Aoki T., Dezawa M., Yusa S., Iitsuka Y., Koseki H., Taniguchi M., Tokuhisa T.
RT A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice
RL J. Clin. Invest. 100:795-801 (1997).
RN [4]; RE0016874.
RX PUBMED: 10869550.
RA Shimizu H., Kang M., Iitsuka Y., Ichinose M., Tokuhisa T., Hatano M.
RT Identification of an optimal Ncx binding sequence required for transcriptional activation
RL FEBS Lett. 475:170-174 (2000).
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