
AC   T02080
XX
ID   T02080
XX
DT   29.01.1997 (created); ewi.
DT   30.09.2008 (updated); pwa.
CO   Copyright (C), QIAGEN.
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FA   Otx1
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SY   orthodenticle related homeobox protein 1.
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OS   mouse, Mus musculus
OC   eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE   G006518 Otx1.
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HO   Otd (Drosophila) T02078.
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CL   C0006; homeo; 3.1.3.17.1.
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CP   rostral brain: dorsal and most ventral regions of telencephalon, diencephalon, mesencephalon (day 10) [1]; 3,5 kb transcript from 10,5 dpc to 15,5 dpc mouse embryos; expression in the mesencephalon, diencephalon [4] [4] [1].
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FF   weak transcriptional activator [3];
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MX   M08892 V$CRX_Q6.
MX   M01366 V$OTX1_01.
MX   M04423 V$OTX1_06.
MX   M03838 V$OTX1_Q5.
MX   M01117 V$OTX_Q1.
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BS   R15733.
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DR   TRANSPATH: MO000026146.
DR   UniProtKB: P80205;
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RN   [1]; RE0005031.
RX   PUBMED: 1353865.
RA   Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Rambaldi M., Boncinelli E.
RT   Nested expression domains of four homeobox genes in developing rostral brain
RL   Nature 358:687-690 (1992).
RN   [2]; RE0005172.
RX   PUBMED: 8101484.
RA   Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M. R., Nigro V., Boncinelli E.
RT   A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
RL   EMBO J. 12:2735-2747 (1993).
RN   [3]; RE0015734.
RX   PUBMED: 9371841.
RA   Smidt M. P., van Schaick H. S., Lanctot C., Tremblay J. J., Cox J. J., van der Kleij A. A., Wolterink G., Drouin J., Burbach J. P.
RT   A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
RL   Proc. Natl. Acad. Sci. USA 94:13305-13310 (1997).
RN   [4]; RE0024916.
RX   PUBMED: 12055180.
RA   Zhang Y., Miki T., Iwanaga T., Koseki Y., Okuno M., Sunaga Y., Ozaki N., Yano H., Koseki H., Seino S.
RT   Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family.
RL   J. Biol. Chem. 277:28065-28069 (2002).
XX
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