AC T02337
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ID T02337
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DT 26.01.1998 (created); ili.
DT 26.06.2009 (updated); pum.
CO Copyright (C), QIAGEN.
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FA ALL1
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SY ALL1; HRX; HTRX; MLL.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001428 KMT2A; HGNC: KMT2A.
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CL C0070; CXXC; 2.6.1.0.4.
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SF 6 zinc finger-like motifs [1];
SF alternative zinc finger-like motifs [2];
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FF related to leukemias that involve rearrangement of chromosome 11q23 [1];
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IN T00118 HCF1-isoform1; human, Homo sapiens.
IN T25630 HCF1; human, Homo sapiens.
IN T10617 NF-YC; human, Homo sapiens.
IN T21600 nucleolin; human, Homo sapiens.
IN T09103 TAFII70; human, Homo sapiens.
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DR TRANSPATH: MO000026333.
DR UniProtKB: Q03164;
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RN [1]; RE0006532.
RX PUBMED: 1423625.
RA Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G., Croce C. M., Canaani E.
RT The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila thrthorax, to the AF-4 gene
RL Cell 71:701-708 (1992).
RN [2]; RE0006535.
RX PUBMED: 1423624.
RA Tkachuk D. C., Kohler S., Cleary M. L.
RT Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
RL Cell 71:691-700 (1992).
RN [3]; RE0062796.
RX PUBMED: 15199122.
RA Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D. J., Kitabayashi I., Herr W., Cleary M. L.
RT Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.
RL Mol. Cell. Biol. 24:5639-5649 (2004).
RN [4]; RE0062933.
RX PUBMED: 12482972.
RA Hsieh J. J., Ernst P., Erdjument-Bromage H., Tempst P., Korsmeyer S. J.
RT Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
RL Mol. Cell. Biol. 23:186-194 (2003).
RN [5]; RE0062956.
RX PUBMED: 14636557.
RA Hsieh J. J., Cheng E. H., Korsmeyer S. J.
RT Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
RL Cell 115:293-303 (2003).
RN [6]; RE0062977.
RX PUBMED: 12393701.
RA Yokoyama A., Kitabayashi I., Ayton P. M., Cleary M. L., Ohki M.
RT Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.
RL Blood 100:3710-3718 (2002).
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