TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02337 XX ID T02337 XX DT 26.01.1998 (created); ili. DT 26.06.2009 (updated); pum. CO Copyright (C), QIAGEN. XX FA ALL1 XX SY ALL1; HRX; HTRX; MLL. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001428 KMT2A; HGNC: KMT2A. XX CL C0070; CXXC; XX SF 6 zinc finger-like motifs [1]; SF alternative zinc finger-like motifs [2]; XX FF related to leukemias that involve rearrangement of chromosome 11q23 [1]; XX IN T00118 HCF1-isoform1; human, Homo sapiens. IN T25630 HCF1; human, Homo sapiens. IN T10617 NF-YC; human, Homo sapiens. IN T21600 nucleolin; human, Homo sapiens. IN T09103 TAFII70; human, Homo sapiens. XX DR TRANSPATH: MO000026333. DR UniProtKB: Q03164; XX RN [1]; RE0006532. RX PUBMED: 1423625. RA Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G., Croce C. M., Canaani E. RT The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila thrthorax, to the AF-4 gene RL Cell 71:701-708 (1992). RN [2]; RE0006535. RX PUBMED: 1423624. RA Tkachuk D. C., Kohler S., Cleary M. L. RT Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias RL Cell 71:691-700 (1992). RN [3]; RE0062796. RX PUBMED: 15199122. RA Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D. J., Kitabayashi I., Herr W., Cleary M. L. RT Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. RL Mol. Cell. Biol. 24:5639-5649 (2004). RN [4]; RE0062933. RX PUBMED: 12482972. RA Hsieh J. J., Ernst P., Erdjument-Bromage H., Tempst P., Korsmeyer S. J. RT Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. RL Mol. Cell. Biol. 23:186-194 (2003). RN [5]; RE0062956. RX PUBMED: 14636557. RA Hsieh J. J., Cheng E. H., Korsmeyer S. J. RT Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. RL Cell 115:293-303 (2003). RN [6]; RE0062977. RX PUBMED: 12393701. RA Yokoyama A., Kitabayashi I., Ayton P. M., Cleary M. L., Ohki M. RT Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. RL Blood 100:3710-3718 (2002). XX //