AC T02344
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ID T02344
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DT 13.02.1998 (created); tme.
DT 28.10.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA HNF-3beta
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SY forkhead box A2; Foxa2; HNF-3B; HNF3; HNF3B; HNF3beta; Tcf-3b; Tcf3b.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001010 Foxa2.
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CL C0023; fork head; 3.3.1.1.2.
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SF gene located on chromosome 2 [1];
SF three different 5' exons -> three mRNAs and potentially two different translation products [6];
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CP (embryonic) node, neural fold, forebrain, floorplate, notochord, gut, inner organs [2], visceral endoderm [12]; (adult) lung, liver, stomach, intestine, heart(-), fat(-) [4] [2] [4] [12].
CN ES-cells; (adult) brain, skeleton muscle, kidney, thymus, spleen, ovary, testis [4].
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FF ectopic expression induces floor plate-like structures and expression of several floor plate markers (e.g. HNF-3alpha T02343) [6];
FF knock out leads to loss of node and notochord formation during embryogenesis [7] [8];
FF expression in the neural plate (embryonal) is induced by sonic hedgehog (Shh) [10] [11];
FF inhibited by insulin through phosphorylation and nuclear exclusion in liver [13];
FF increased nuclear localization during fasting (low insulin) [13];
FF regulates lipid metabolism and ketogenesis during fasting [13];
FF in diabetic models: localized exclusively in the cytosol of hepatocytes from both, fed and starved mice [13];
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MX M02853 V$FOXA2_02.
MX M02749 V$FOXA2_04.
MX M04649 V$FOXA2_05.
MX M00131 V$HNF3B_01.
MX M02014 V$HNF3B_Q6.
MX M00791 V$HNF3_Q6.
MX M01012 V$HNF3_Q6_01.
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BS R26298.
BS R17151.
BS R17150.
BS R17157.
BS R26448.
BS R26568.
BS R15361.
BS R30216.
BS R26445.
BS R20796.
BS R20206.
BS R33785.
BS R33787.
BS R40128.
BS R73160.
BS R18136.
BS R19240.
BS R31579.
BS R25965.
BS R25805.
BS R01464.
BS R04658.
BS R00581.
BS R26408.
BS R26569.
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DR TRANSPATH: MO000045364.
DR UniProtKB: P35583;
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RN [1]; RE0006565.
RX PUBMED: 1612587.
RA Avraham K. B., Prezioso V. R., Chen W. S., Lai E., Sladek F. M., Zhong W., Darnell jr J. E., Jenkins N. A., Copeland N. G.
RT Murine Chromosomal Location of Four Hepatocyte-Enriched Transcription Factors: HNF-3alpha, HNF-3beta, HNF-3gamma, and HNF-4
RL Genomics 13:264-268 (1992).
RN [2]; RE0006566.
RX PUBMED: 8375339.
RA Sasaki H., Hogan B. L. M.
RT Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
RL Development 118:47-59 (1993).
RN [3]; RE0006568.
RX PUBMED: 8187630.
RA Monaghan A. P., Kaestner K. H., Grau E., Schuetz G.
RT Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm
RL Development 119:567-578 (1993).
RN [4]; RE0006573.
RX PUBMED: 8034310.
RA Kaestner K. H., Hiemisch H., Luckow B., Schuetz G.
RT The HNF-3 Gene Familiy of Transcription Factors in Mice: Gene Structure, cDNA Sequence, and mRNA Distribution
RL Genomics 20:377-385 (1994).
RN [5]; RE0006575.
RX PUBMED: 8306889.
RA Ang S.-L., Wierda A., Wong D., Stevens K. A., Cascio S., Rossant J., Zaret K. S.
RT The formation and maintenance of the definitve endoderm lineage in the mouse: involvemant of HNF3/forkhead proteins
RL Development 119:1301-1315 (1993).
RN [6]; RE0006577.
RX PUBMED: 8287471.
RA Sasaki H., Hogan B. L. M.
RT HNF-3beta as a Regulator of Floor Plate Development
RL Cell 76:103-115 (1994).
RN [7]; RE0006600.
RX PUBMED: 8069909.
RA Ang S.-L., Rossant J.
RT HNF-3beta is essential for node and notochord formation in mouse development
RL Cell 78:561-574 (1994).
RN [8]; RE0006601.
RX PUBMED: 8069910.
RA Weinstein D. C., Ruiz i Altaba A., Chen W. S., Hoodless P., Prezioso V. R., Jessell T. M., Darnell jr J. E.
RT The winged-helix transcription factor HNF-3beta is required for notochord development in the mouse embryo
RL Cell 78:575-588 (1994).
RN [9]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [10]; RE0006701.
RX PUBMED: 8837770.
RA Chiang C., Litingtung Y., Lee E., Young K. E., Corden J. L., Westphal H., Beachy P. A.
RT Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
RL Nature 383:407-413 (1996).
RN [11]; RE0006702.
RX PUBMED: 8929535.
RA Ericson J., Morton S., Kawakami A., Roelink H., Jessell T. M.
RT Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
RL Cell 87:661-673 (1996).
RN [12]; RE0006970.
RX PUBMED: 9152011.
RA Farrington S. M., Belaoussoff M., Baron M. H.
RT Winged-Helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac
RL Mech. Dev. 62:197-211 (1997).
RN [13]; RE0025434.
RX PUBMED: 15616563.
RA Wolfrum C., Asilmaz E., Luca E., Friedman J. M., Stoffel M.
RT Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.
RL Nature 432:1027-1032 (2004).
RN [14]; RE0048853.
RX PUBMED: 15541382.
RA van der Sluis M., Melis M. H., Jonckheere N., Ducourouble M. P., Buller H. A., Renes I., Einerhand A. W., Van Seuningen I.
RT The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.
RL Biochem. Biophys. Res. Commun. 325:952-960 (2004).
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