AC T02374
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ID T02374
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DT 01.04.1998 (created); ili.
DT 12.01.2011 (updated); din.
CO Copyright (C), QIAGEN.
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FA Rb
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OS monkey, Cercopithecus aethiops
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates; haplorhini; catarrhini; cercopithecidae; cercopithecinae
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SF phosphorylation of Rb is cell cycle-dependent: Rb is unphosphorylated in G0/G1, gets phosphorylated at the beginning of S and remains phosphorylated until the end of G2 [4] [5];
SF only unphosphorylated Rb can be found complexed with SV40 T-Ag [3] [5];
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IN T00788 T-Ag; SV40, simian virus 40.
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BS R04915.
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DR TRANSPATH: MO000026364.
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RN [1]; RE0006713.
RX PUBMED: 8007947.
RA Chen L. I., Nishinaka T., Kwan K., Kitabayashi I., Yokoyama K., Fu Y.-H. F., Gruenwald S., Chiu R.
RT The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator
RL Mol. Cell. Biol. 14:4380-4389 (1994).
RN [2]; RE0013304.
RX PUBMED: 2839300.
RA DeCaprio J. A., Ludlow J. W., Figge J., Shew J.-Y., Huang C.-M., Lee W.-H., Marsilio E., Paucha E., Livingston D. M.
RT SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene.
RL Cell 54:275-283 (1988).
RN [3]; RE0013305.
RX PUBMED: 2910497.
RA Ludlow J. W., DeCaprio J. A., Huang C.-M., Lee W.-H., Paucha E., Livingston D. M.
RT SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family.
RL Cell 56:57-65 (1989).
RN [4]; RE0013306.
RX PUBMED: 2673542.
RA DeCaprio J. A., Ludlow J. W., Lynch D., Furukawa Y., Griffin J., Piwnica-Worms H., Huang C.-M., Livingston D. M.
RT The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.
RL Cell 58:1085-1095 (1989).
RN [5]; RE0013307.
RX PUBMED: 2154332.
RA Ludlow J. W., Shon J., Pipas J. M., Livingston D. M., DeCaprio J. A.
RT The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.
RL Cell 60:387-396 (1990).
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