TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02384 XX ID T02384 XX DT 07.04.1998 (created); tme. DT 05.09.2013 (updated); sup. CO Copyright (C), QIAGEN. XX FA NKX2B XX SY Nkx-2.2; NKX2B. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002535 Nkx2-2. XX HO TTF-1. XX CL C0053; NK-2/Nkx; XX CP (embryo and adult:) brain [1]; pancreatic islets into adulthood [6]; alpha- and beta- cells [6]. CN (adult) thyroid, kidney, heart and skeletal muscle, liver, intestine, thymus, stomach [1]; exocrine tissue [6]; delta cells [6]. XX FF Disruption of the Nkx2.2 gene leads to a loss in -cell neogenesis during the secondary transition, resulting in hyperglycemia and profoundly increased numbers of ghrelin-producing islet epsilon cells [7]; FF NKX2B is required for the final differentiation of pancreatic beta-cells (insulin-producing beta cells) [6]; FF acts upstream of Nkx6-1 T04269 in the pathway of beta-cell differentiation [3]; XX MX M00485 V$NKX22_01. MX M01372 V$NKX22_02. MX M02109 V$NKX2B_Q3. MX M07391 V$NKX2B_Q3_01. XX BS R57821. BS R35712. BS R35713. BS R19211. BS R39948. BS R40006. BS R20799. BS R31394. BS R18138. XX DR TRANSPATH: MO000026374. DR UniProtKB: P42586; XX RN [1]; RE0006773. RX PUBMED: 1346742. RA Price M., Lazzaro D., Pohl T., Mattei M-G., Ruether U., Olivo J-C., Duboule D., Di Lauro R. RT Regional expression of the Homeobox gene Nkx-2.2 in the developing mammalian forebrain RL Neuron 8:241-255 (1992). RN [2]; RE0015674. RX PUBMED: 9533954. RA Qiu M., Shimamura K., Sussel L., Chen S., Rubenstein J. L. RT Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development RL Mech. Dev. 72:77-88 (1998). RN [3]; RE0016336. RX PUBMED: 11076772. RA Sander M., Sussel L., Conners J., Scheel D., Kalamaras J., Dela Cruz F., Schwitzgebel V., Hayes-Jordan A., German M. RT Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas RL Development 127:5533-5540 (2000). RN [4]; RE0047067. RX PUBMED: 10607393. RA Hynes M., Ye W., Wang K., Stone D., Murone M., Sauvage F., Rosenthal A. RT The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types RL Nat. Neurosci. 3:41-6 (2000). RN [5]; RE0066684. RX PUBMED: 19223390. RA Patterson V. L., Damrau C., Paudyal A., Reeve B., Grimes D. T., Stewart M. E., Williams D. J., Siggers P., Greenfield A., Murdoch J. N. RT Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. RL Hum. Mol. Genet. 18:1719-1739 (2009). RN [6]; RE0047587. RX PUBMED: 9584121. RA Sussel L., Kalamaras J., Hartigan-O'Connor D. J., Meneses J. J., Pedersen R. A., Rubenstein J. L., German M. S. RT Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. RL Development 125:2213-2221 (1998). RN [7]; RE0049612. RX PUBMED: 16847327. RA Raum J. C., Gerrish K., Artner I., Henderson E., Guo M., Sussel L., Schisler J. C., Newgard C. B., Stein R. RT FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. RL Mol. Cell. Biol. 26:5735-5743 (2006). XX //