AC T04269
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ID T04269
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DT 30.01.2001 (created); rio.
DT 13.05.2011 (updated); pch.
CO Copyright (C), QIAGEN.
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FA NKX6A
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SY Nkx-6.1; Nkx6.1; Nkx6A.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002539 Nkx6-1.
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CL C0006; homeo; 3.1.2.19.1.
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SF NKX6A -/- mice show a profound deficiency of insulin-expressing beta-cells [2];
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EX pancreas primordium,epithelial cell,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX pancreas,beta cell of island of Langerhans,,Theiler Stage 24; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX pancreas,ductal epithelial cell of pancreas,,Theiler Stage 24; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX pancreas,epithelial cell,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX pancreas,periductal cell,,Theiler Stage 24; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX ventral region of neural tube,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
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FF acts downstream of Nkx2-2 T02384 in the pathway of beta-cell neogenesis during the secondary transition of beta-cell differentiation [2];
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MX M00424 V$NKX61_01.
MX M01469 V$NKX61_02.
MX M01489 V$NKX61_03.
MX M07399 V$NKX61_08.
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BS R35230.
BS R31595.
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DR TRANSPATH: MO000028134.
DR UniProtKB: Q99MA9;
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RN [1]; RE0015674.
RX PUBMED: 9533954.
RA Qiu M., Shimamura K., Sussel L., Chen S., Rubenstein J. L.
RT Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
RL Mech. Dev. 72:77-88 (1998).
RN [2]; RE0016336.
RX PUBMED: 11076772.
RA Sander M., Sussel L., Conners J., Scheel D., Kalamaras J., Dela Cruz F., Schwitzgebel V., Hayes-Jordan A., German M.
RT Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
RL Development 127:5533-5540 (2000).
RN [3]; RE0066684.
RX PUBMED: 19223390.
RA Patterson V. L., Damrau C., Paudyal A., Reeve B., Grimes D. T., Stewart M. E., Williams D. J., Siggers P., Greenfield A., Murdoch J. N.
RT Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.
RL Hum. Mol. Genet. 18:1719-1739 (2009).
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