AC T02417
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ID T02417
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DT 24.04.1998 (created); ewi.
DT 19.04.2010 (updated); bjo.
CO Copyright (C), QIAGEN.
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FA FOXL1
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SY Fkh-6; FKHL11; Fork head homolog 6; Freac-7 (Forkhead RElated ACtivator-7).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006099 Foxl1.
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CL C0023; fork head; 3.3.1.12.1.
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SF gene located on chromosome 8 [3];
SF knock out leads to profound alterations in the gastric and intestinal epithelia from late fetal period on [1];
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CP (embryonic) (d 8 pc) posterior mesoderm, (d 9.5 pc) mesenchyme of head, lung and gut [3]; (adult) stomach, intestine, kidney (weak) [2] [2] [3].
CN (adult) brain, muscle, heart, fat, lung, liver, pancreas, thymus, spleen, gonads [2].
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FF for expression in teeth, see [4];
FF gene locus is very close to locus of MFH-1 T02445 [3];
FF in the K.O. mice the expression of Bmp2 (in stomach, duodenum and jejunum) and Bmp4 (in stomach) is reduced [1];
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MX M02857 V$FOXL1_02.
MX M02753 V$FOXL1_04.
MX M00293 V$FREAC7_01.
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DR TRANSPATH: MO000026404.
DR UniProtKB: Q64731;
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RN [1]; RE0006042.
RX PUBMED: 9203584.
RA Kaestner K. H., Silberg D. G., Traber P. G., Schuetz G.
RT The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation
RL Genes Dev. 11:1583-1595 (1997).
RN [2]; RE0006823.
RX PUBMED: 7689224.
RA Kaestner K. H., Lee K. H., Schloendorff J., Hiemisch H., Monaghan A. P., Schuetz G.
RT Six members of the mouse forkhead gene family are developmentally regulated
RL Proc. Natl. Acad. Sci. USA 90:7628-7631 (1993).
RN [3]; RE0006824.
RX PUBMED: 8674414.
RA Kaestner K. H., Bleckmann S. C., Monaghan A. P., Schloendorff J., Mincheva A., Lichter P., Schuetz G.
RT Clustered arrangements of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development
RL Development 122:1751-1758 (1996).
RN [4]; RE0014828.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/FKH6.htm
RL Internet : (1996).
RN [5]; RE0066561.
RX PUBMED: 15188402.
RA Hassel S., Eichner A., Yakymovych M., Hellman U., Knaus P., Souchelnytskyi S.
RT Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.
RL Proteomics 4:1346-1358 (2004).
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