TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02445 XX ID T02445 XX DT 05.05.1998 (created); tme. DT 30.07.2014 (updated); sla. CO Copyright (C), QIAGEN. XX FA FKHL14 XX SY Fkh-14; Fkh14; Fork head homolog 14; FOXC2; Hfhbf3; Mesenchyme fork head 1; MFH-1; Mfh1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014324 Foxc2. XX CL C0023; fork head; XX SF gene is located on chromosome 8 [2]; XX CP (embryonic) mesoderm (earlier), mesenchyme and derivatives (later, mainly head region) [3], dorsal aortas [6]; (adult) muscle, heart, kidney, (weaker in) brain, fat, lung, liver, gonads [2] [2] [3] [6]. CN (embryonal) node, endoderm, ectoderm, extraembryonic regions; (adult) pancreas, thymus, spleen. XX FF is required for the early organogenesis of the kidney and urinary tract [8]; FF play interactive roles in the morphogenesis of the cardiovascular system [7]; FF play pivotal roles in the early processes of heart development, especially acting upstream of the Tbx1-FGF cascade during the morphogenesis of the outflow tract [9]; FF gene locus is very close to locus of Fkh-6 T02417 [2]; FF K.O. mice die in most cases prenatally (beginning 13.5 dpc); FF surviving animals show severe craniofacial and vertebral defects, which may be due to the marked reduction in the proliferation and (probably) the differentiation of sclerotome derived cell lineages [4]; FF mutant mice also show a type B interruption of the (fourth) aortic arch [6]; FF the expression pattern is (almost) identical to that of Fkh-1 T02426, but seems to be stronger in the inner layers of the developing cartilage [5]; XX MX M08882 V$FKHL14_Q2. XX DR TRANSPATH: MO000046084. DR UniProtKB: Q61850; MFH1_MOUSE. XX RN [1]; RE0006655. RA TRANSFAC_Team. RT Revisions of transcription factor domains RL TRANSFAC Reports 1:0002 (1998). RN [2]; RE0006824. RX PUBMED: 8674414. RA Kaestner K. H., Bleckmann S. C., Monaghan A. P., Schloendorff J., Mincheva A., Lichter P., Schuetz G. RT Clustered arrangements of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development RL Development 122:1751-1758 (1996). RN [3]; RE0006846. RX PUBMED: 8325367. RA Miura N., Wanaka A., Tohyama M., Tanaka K. RT MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme RL FEBS Lett. 326:171-176 (1993). RN [4]; RE0006922. RX PUBMED: 9106663. RA Winnier G. E., Hargett L., Hogan B. L. M. RT The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo RL Genes Dev. 11:926-940 (1997). RN [5]; RE0006937. RX PUBMED: 9545561. RA Hiemisch H., Monaghan A. P., Schuetz G., Kaestner K. H. RT Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives RL Mech. Dev. 73:129-132 (1998). RN [6]; RE0006969. RX PUBMED: 9409679. RA Iida K., Koseki H., Kakinuma H., Kato N., Mizutani-Koseki Y., Ohuchi H., Yoshioka H., Noji S., Kawamura K., Kataoka Y., Ueno F., Taniguchi M., Yoshida N., Sugiyama T., Miura N. RT Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis RL Development 124:4627-4638 (1997). RN [7]; RE0047979. RX PUBMED: 10479458. RA Winnier G. E., Kume T., Deng K., Rogers R., Bundy J., Raines C., Walter M. A., Hogan B. L., Conway S. J. RT Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. RL Dev. Biol. 213:418-431 (1999). RN [8]; RE0047980. RX PUBMED: 10704385. RA Kume T., Deng K., Hogan B. L. RT Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. RL Development 127:1387-1395 (2000). RN [9]; RE0047981. RX PUBMED: 16839542. RA Seo S., Kume T. RT Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. RL Dev. Biol. 296:421-436 (2006). XX //