AC T02426
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ID T02426
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DT 29.04.1998 (created); tme.
DT 29.07.2014 (updated); sla.
CO Copyright (C), QIAGEN.
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FA foxc1
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SY Fkh-1; FKHL7; Forkhead box protein C1; FREAC3; Mf1 (Mesoderm/Mesenchyme forkhead 1).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014323 Foxc1.
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CL C0023; fork head; 3.3.1.3.1.
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SF may be autolog to drosophila croc T02291;
SF gene located on chromosome 8 [5];
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CP (embryonic) prechondrogenic mesenchyme and derivatives: cartilage primordia of head, ribs, vertebra and bones [1]; (adult) brain, heart, kidney, fat, lung and thymus (weak), adrenal [6] [1] [6].
CN (adult) liver [6].
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FF is necessary for the normal development of the cornea and formation of the anterior chamber in eyes [9];
FF is required for the early organogenesis of the kidney and urinary tract [11];
FF play interactive roles in the morphogenesis of the cardiovascular system [10];
FF play pivotal roles in the early processes of heart development, especially acting upstream of the Tbx1-FGF cascade during the morphogenesis of the outflow tract [12];
FF Null mutation in mice causes phenotype similar/identical to congenital hydrocephalus (ch);
FF a point mutation, that causes a premature stop codon, correlates with the phenotype;
FF deletions of the distal region of human chromosome 6, where the human homolog, Freac-3 T02471, is located, result in phenotypes similar to ch [4];
FF the expression pattern is (almost) identical to that of Mfh-1 T02445, but seems to be weaker in the inner layers of the developing cartilage [6];
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MX M04269 V$FOXC1_06.
MX M07254 V$FOXC1_Q4.
MX M00291 V$FREAC3_01.
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DR TRANSPATH: MO000046083.
DR UniProtKB: Q61572; FRE3_MOUSE.
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RN [1]; RE0006566.
RX PUBMED: 8375339.
RA Sasaki H., Hogan B. L. M.
RT Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
RL Development 118:47-59 (1993).
RN [2]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [3]; RE0006823.
RX PUBMED: 7689224.
RA Kaestner K. H., Lee K. H., Schloendorff J., Hiemisch H., Monaghan A. P., Schuetz G.
RT Six members of the mouse forkhead gene family are developmentally regulated
RL Proc. Natl. Acad. Sci. USA 90:7628-7631 (1993).
RN [4]; RE0006920.
RX PUBMED: 9635428.
RA Kume T., Deng K.-Y., Winfrey V., Gould D. B., Walter M. A., Hogan B. L. M.
RT The Forkhead/Winged Helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus
RL Cell 93:985-996 (1998).
RN [5]; RE0006921.
RX PUBMED: 8661058.
RA Labosky P. A., Winnier G. E., Sasaki H., Blessing M., Hogan B. L. H.
RT The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development
RL Genomics 34:241-245 (1996).
RN [6]; RE0006937.
RX PUBMED: 9545561.
RA Hiemisch H., Monaghan A. P., Schuetz G., Kaestner K. H.
RT Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives
RL Mech. Dev. 73:129-132 (1998).
RN [7]; RE0047186.
RX PUBMED: 15684392.
RA Berry F. B., O'Neill M. A., Coca-Prados M., Walter M. A.
RT FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
RL Mol. Cell. Biol. 25:1415-24 (2005).
RN [8]; RE0047915.
RX PUBMED: 11179011.
RA Saleem R. A., Banerjee-Basu S., Berry F. B., Baxevanis A. D., Walter M. A.
RT Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1.
RL Am. J. Hum. Genet. 68:627-641 (2001).
RN [9]; RE0047978.
RX PUBMED: 10395790.
RA Kidson S. H., Kume T., Deng K., Winfrey V., Hogan B. L.
RT The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye.
RL Dev. Biol. 211:306-322 (1999).
RN [10]; RE0047979.
RX PUBMED: 10479458.
RA Winnier G. E., Kume T., Deng K., Rogers R., Bundy J., Raines C., Walter M. A., Hogan B. L., Conway S. J.
RT Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles.
RL Dev. Biol. 213:418-431 (1999).
RN [11]; RE0047980.
RX PUBMED: 10704385.
RA Kume T., Deng K., Hogan B. L.
RT Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.
RL Development 127:1387-1395 (2000).
RN [12]; RE0047981.
RX PUBMED: 16839542.
RA Seo S., Kume T.
RT Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract.
RL Dev. Biol. 296:421-436 (2006).
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