AC T02421
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ID T02421
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DT 28.04.1998 (created); ewi.
DT 03.09.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha2
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SY hepatocyte nuclear factor 4; hepatocyte nuclear factor 4alpha1; HNF-4; HNF-4A; HNF4; NR2A1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001926 HNF4A; HGNC: HNF4A.
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CL C0002; CC (rec); 2.1.3.2.1.2.
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SZ 464 AA; 51.6 kDa (cDNA) (calc.).
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SQ MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
SQ AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
SQ FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
SQ IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
SQ DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
SQ GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
SQ FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMSTP
SQ ETPQPSPPGASGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
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SC edited Swiss-Prot #P41235
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FT 1 59 
A/B region [4].
FT 11 388 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 57 128 
SM00399; c4gold.
FT 57 132 
PS51030; NUCLEAR_REC_DBD_2.
FT 58 133 
PF00105; Zinc finger, C4 type (two domains).
FT 60 125 
C region (DNA binding) [4].
FT 126 136 
T box [6].
FT 126 142 
D region [4].
FT 138 144 
A box, PKA phosphorylation recognition site [6].
FT 143 377 
E region (ligand binding) [4].
FT 189 348 SM00430; holi.
FT 192 373 PF00104; Ligand-binding domain of nuclear hormon.
FT 378 464 F region [4].
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SF the originally published 455-AA sequence may lack an authentic N-terminal 9-AA stretch [4];
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IN T02428 HNF-4alpha3; human, Homo sapiens.
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M02220 V$HNF4A_03.
MX M07321 V$HNF4A_Q3.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R04591.
BS R02179.
BS R04454.
BS R33048.
BS R33053.
BS R20937.
BS R20940.
BS R15939.
BS R23474.
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DR TRANSPATH: MO000026407.
DR TRANSCOMPEL: C00521.
DR TRANSCOMPEL: C00522.
DR TRANSCOMPEL: C00628.
DR UniProtKB: P41235-2;
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RN [1]; RE0001457.
RX PUBMED: 2325638.
RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B.
RT Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene
RL Mol. Cell. Biol. 10:1841-1852 (1990).
RN [2]; RE0001476.
RX PUBMED: 2786140.
RA Costa R. H., Grayson D. R., Darnell J. E.
RT Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha1-antitrypsin genes
RL Mol. Cell. Biol. 9:1415-1425 (1989).
RN [3]; RE0006828.
RX PUBMED: 7926813.
RA Chartier F. L., Bossu J.-P., Laudet V., Fruchart J.-C., Laine B.
RT Full sequence of the human HNF4 cDNA
RL Gene 147:269-272 (1994).
RN [4]; RE0006831.
RX PUBMED: 8622695.
RA Drewes T., Senkel S., Holewa B., Ryffel G. U.
RT Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes
RL Mol. Cell. Biol. 16:925-931 (1996).
RN [5]; RE0006833.
RX PUBMED: 8964514.
RA Kritis A. A., Argyrokastritis A., Moschonas N. K., Power S., Katrakili N., Zannis V. I., Cereghini S., Talianidis I.
RT Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4
RL Gene 173:275-280 (1996).
RN [6]; RE0018065.
RX PUBMED: 9234678.
RA Viollet B., Kahn A., Raymondjean M.
RT Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.
RL Mol. Cell. Biol. 17:4208-4219 (1997).
RN [7]; RE0038049.
RX PUBMED: 11916906.
RA Iwahashi H., Yamagata K., Yoshiuchi I., Terasaki J., Yang Q., Fukui K., Ihara A., Zhu Q., Asakura T., Cao Y., Imagawa A., Namba M., Hanafusa T., Miyagawa J., Matsuzawa Y.
RT Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha
RL Diabetes 51:910-4 (2002).
RN [8]; RE0066471.
RX PUBMED: 18513187.
RA Guo D., Dong L. Y., Wu Y., Yang L., An W.
RT Down-regulation of hepatic nuclear factor 4alpha on expression of human hepatic stimulator substance via its action on the proximal promoter in HepG2 cells.
RL Biochem. J. 415:111-121 (2008).
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