AC T02428
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ID T02428
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DT 29.04.1998 (created); ewi.
DT 14.01.2008 (updated); djp.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha3
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SY hepatocyte nuclear factor 4alpha3; HNF-4C; HNF4alpha3; NR2A1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001926 HNF4A; HGNC: HNF4A.
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CL C0002; CC (rec); 2.1.3.2.1.3.
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SZ 408 AA; 45.6 kDa (cDNA) (calc.).
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SQ MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATG
SQ KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA
SQ VQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCE
SQ SMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY
SQ IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIK
SQ RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL
SQ LQEMLLGGPCQAQEGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA
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SC SPTREMBL #Q92654
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FT 2 378 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 48 119 
SM00399; c4gold.
FT 48 123 
PS51030; NUCLEAR_REC_DBD_2.
FT 49 124 
PF00105; Zinc finger, C4 type (two domains).
FT 180 339 
SM00430; holi.
FT 183 364 
PF00104; Ligand-binding domain of nuclear hormon.
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SF the published sequence may lack an additional N-terminal 9-AA stretch [2];
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FF activator, similar trans-activation capability as HNF-4alpha1 and -alpha2 [3];
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IN T00373 HNF-4alpha1; human, Homo sapiens.
IN T02421 HNF-4alpha2; human, Homo sapiens.
IN T10924 islet1; rat, Rattus norvegicus.
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M07321 V$HNF4A_Q3.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R04591.
BS R02179.
BS R04454.
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DR TRANSPATH: MO000026413.
DR EMBL: U72959;
DR EMBL: U72961;
DR EMBL: U72962;
DR EMBL: U72963;
DR EMBL: U72964;
DR EMBL: U72965;
DR EMBL: U72966;
DR EMBL: U72967;
DR EMBL: X87872;
DR UniProtKB: P41235-3;
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RN [1]; RE0006179.
RX PUBMED: 8945471.
RA Yamagata K., Furuta H., Oda N., Kaisaki P. J., Menzel S., Cox N. J., Fajans S. S., Signorini S., Stoffel M., Bell G. I.
RT Mutations in the hepatocyte nuclear factor-4alpha in maturity-onset diabetes of the young (MODY1)
RL Nature 384:458-460 (1996).
RN [2]; RE0006831.
RX PUBMED: 8622695.
RA Drewes T., Senkel S., Holewa B., Ryffel G. U.
RT Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes
RL Mol. Cell. Biol. 16:925-931 (1996).
RN [3]; RE0006833.
RX PUBMED: 8964514.
RA Kritis A. A., Argyrokastritis A., Moschonas N. K., Power S., Katrakili N., Zannis V. I., Cereghini S., Talianidis I.
RT Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4
RL Gene 173:275-280 (1996).
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