AC T02470
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ID T02470
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DT 10.06.1998 (created); ewi.
DT 08.06.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA AP-2gamma
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SY activator protein 2gamma; AP-2.2 (mouse); Tcfap2c.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006797 Tfap2c.
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CL C0032; bHSH; 1.3.1.0.3.
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CP (adult:) lung, ovary, testis; squamous epithelia [1]; highly expressed in placenta; AP-2gamma is the major AP-2 transcript present in placenta, much more higher than that of AP-2alpha T00033 [5]; AP-2gamma is present at every stage and in every branch of trophoblast cells during placental development shown by in situ hybridization [5]; E14.5 cells [3].
CN brain, heart, kidney, liver, spleen [1].
EX Hypothalamus primordium,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX brain,,,adult; none; Northern blot; total RNA; [5].
EX central nervous system,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX central nervous system,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX cerebellum,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX cerebral cortex,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX cerebral cortex,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX corpus striatum,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX cranial sensory ganglion,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX cranial sensory ganglion,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX ear,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX ear,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX epithelium of olfactory region of nasal cavity,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX epithelium of olfactory region of nasal cavity,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX future corpus striatum,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX heart,,,adult; detectable; Northern blot; total RNA; [5].
EX hypothalamus,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [5].
EX large intestine,,,adult; none; Northern blot; total RNA; [5].
EX liver,,,adult; none; Northern blot; total RNA; [5].
EX mesencephalon,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX mesencephalon,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX placenta,,,Theiler Stage 22; very high; Northern blot; total RNA; [5].
EX retina,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX retina,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX rhombencephalon,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX rhombencephalon,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX small intestine,,,adult; none; Northern blot; total RNA; [5].
EX spinal cord,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX spinal cord,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX stomach,,,adult; none; Northern blot; total RNA; [5].
EX subventricular zone of the MGE (medial ganglionic eminence),,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX subventricular zone of the MGE (medial ganglionic eminence),,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX thalamus,,,P0 (immediately after birth, postnatal development); none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX thalamus,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX thymus,,,adult; none; Northern blot; total RNA; [5].
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FF trophoblast transcriptional regulator [5];
FF activator [1];
FF synergizes with RAR-alpha [1];
FF induced by retinoic acid (in P19 cells) [1];
FF both AP-2gamma and AP-2alpha T00033 can transactivate estrogen receptor (ER) alpha promoter which explains the correlation between AP-2 activity and estrogen receptor expression in breast cancer [2];
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MX M00470 V$AP2GAMMA_01.
MX M07349 V$AP2GAMMA_Q4.
MX M01859 V$AP2GAMMA_Q5.
MX M03811 V$AP2GAMMA_Q5_01.
MX M00800 V$AP2_Q3.
MX M08867 V$AP2_Q4.
MX M00189 V$AP2_Q6.
MX M00915 V$AP2_Q6_01.
MX M02821 V$TCFAP2C_03.
MX M02925 V$TCFAP2C_04.
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BS R18670.
BS R18669.
BS R68142.
BS R72323.
BS R65336.
BS R68139.
BS R21274.
BS R68143.
BS R68141.
BS R62615.
BS R68144.
BS R23014.
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DR TRANSPATH: MO000026451.
DR UniProtKB: Q61312;
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RN [1]; RE0006897.
RX PUBMED: 8660922.
RA Oulad-Abdelghani M., Bouillet P., Chazaud C., Dolle P., Chambon P.
RT AP-2.2: a novel AP2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells
RL Exp. Cell Res. 225:338-347 (1996).
RN [2]; RE0016805.
RX PUBMED: 10497269.
RA McPherson L. A., Weigel R. J.
RT AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs
RL Nucleic Acids Res. 27:4040-4049 (1999).
RN [3]; RE0043910.
RX PUBMED: 12145340.
RA Ben-Zimra M., Koler M., Orly J.
RT Transcription of cholesterol side-chain cleavage cytochrome p450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element
RL Mol. Endocrinol. 16:1864-80 (2002).
RN [4]; RE0025447.
RX PUBMED: 15618518.
RA Gray P. A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D. I., Tsung E. F., Cai Z., Alberta J. A., Cheng L. P., Liu Y., Stenman J. M., Valerius M. T., Billings N., Kim H. A., Greenberg M. E., McMahon A. P., Rowitch D. H., Stiles C. D., Ma Q.
RT Mouse brain organization revealed through direct genome-scale TF expression analysis.
RL Science 306:2255-2257 (2004).
RN [5]; RE0026934.
RX PUBMED: 9765260.
RA Shi D., Kellems R. E.
RT Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development.
RL J. Biol. Chem. 273:27331-8 (1998).
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