AC T02747
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ID T02747
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DT 03.06.1999 (created); mpr.
DT 20.02.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA REVERB-beta
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SY BD73; EAR-1b; EAR1b; NR1D2; orphan nuclear hormone receptor BD73; rev-erb beta; rev-erb-beta; REVERBb.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006488 NR1D2; HGNC: NR1D2.
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CL C0002; CC (rec).
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SZ 579 AA; 64.6 kDa (calc.).
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SQ MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL
SQ ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC
SQ EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP
SQ KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS
SQ SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH
SQ CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI
SQ DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA
SQ KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG
SQ DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI
SQ MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP
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SC translated from EMBL #D16815
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FT 100 172 
SM00399; c4gold.
FT 100 176 
PS51030; NUCLEAR_REC_DBD_2.
FT 101 177 
PF00105; Zinc finger, C4 type (two domains).
FT 204 546 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 407 565 
SM00430; holi.
FT 410 577 
PF00104; Ligand-binding domain of nuclear hormon.
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SF shows high sequence similarity to T02746 [3];
SF binds as a monomer to a DNA sequence which consists of a specific A/T-rich sequence [3];
SF A box, a sequence which has been suggested to mediate monomer binding by other superfamily members, lies closer to the DNA-binding domain than in other nuclear receptors [3];
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CP expressed in many organs and cell lines (e.g. HepG2 cells) [3].
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FF may function (like other members of the Rev-erb family) as a repressor of transcription, compare to [1] [3];
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DR TRANSPATH: MO000026722.
DR EMBL: D16815;
DR UniProtKB: Q14995;
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RN [1]; RE0010605.
RX PUBMED: 7651396.
RA Harding H. P., Lazar M. A.
RT The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat
RL Mol. Cell. Biol. 15:4791-4802 (1995).
RN [2]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [3]; RE0013633.
RX PUBMED: 7997240.
RA Dumas B., Harding H. P., Choi H. S., Lehmann K. A., Chung M., Lazar M. A., Moore D. D.
RT A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb
RL Mol. Endocrinol. 8:996-1005 (1994).
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