TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02746 XX ID T02746 XX DT 03.06.1999 (created); mpr. DT 22.04.2013 (updated); sla. CO Copyright (C), QIAGEN. XX FA Rev-ErbAalpha XX SY EAR1; EAR1A; NR1D1; rev-erb alpha; rev-erb-alpha; REV-ErbAalpha; REVERBa; THRA1; triiodothyronine receptor. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002923 NR1D1; HGNC: NR1D1. XX CL C0002; CC (rec); XX SF shows low, but appreciable, binding to T3R [1]; SF shows high sequence similarity to T02747; SF hinge domain (region D) is very long, over three times longer than that of other nuclear receptor (like e.g. RAR-alpha T00719 and RXR-alpha T01331) [3]; SF this hinge domain is important for transcriptional repression [3]; XX FF can function as transcriptional repressor (like other members of the Rev-erb family) which was shown for the homodimer in reporter gene assay using an artificial binding site [3]; FF homodimerization enhanced upon binding to DNA (binding site R11759) [3]; FF blocks transactivation by ROR-alpha1 [3]; FF represses basal transcription an dRAR through naturally occurring response element in CRBPI gene [3]; XX IN T02746 Rev-ErbAalpha; human, Homo sapiens. IN T00838 T3R-alpha; human, Homo sapiens. XX MX M03884 V$REVERBALPHA_Q6. XX BS R40071. XX DR TRANSPATH: MO000026721. DR UniProtKB: P20393; XX RN [1]; RE0000147. RX PUBMED: 2539258. RA Miyajima N., Horiuchi R., Shibuya S.-I., Matsubara K.-I., Toyoshima K., Yamamoto T. RT Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus RL Cell 57:31-39 (1989). RN [2]; RE0002102. RX PUBMED: 1850510. RA Laudet V., Begue A., Henry-Duthoit C., Joubel A., Martin P., Stehelin D., Saule S. RT Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene RL Nucleic Acids Res. 19:1105-1112 (1991). RN [3]; RE0010605. RX PUBMED: 7651396. RA Harding H. P., Lazar M. A. RT The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat RL Mol. Cell. Biol. 15:4791-4802 (1995). RN [4]; RE0013625. RX PUBMED: 10219237. RA Nuclear Receptors Nomenclature Committee. RT A unified nomenclature system for the nuclear receptor superfamily RL Cell 97:161-163 (1999). RN [5]; RE0013667. RX PUBMED: 1971514. RA Lazar M. A., Jones K. E., Chin W. W. RT Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone RL DNA Cell Biol. 9:77-83 (1990). RN [6]; RE0054989. RX PUBMED: 15604093. RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M. RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. RL Mol. Cell. Proteomics 4:205-213 (2005). XX //