AC T02746
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ID T02746
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DT 03.06.1999 (created); mpr.
DT 22.04.2013 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Rev-ErbAalpha
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SY EAR1; EAR1A; NR1D1; rev-erb alpha; rev-erb-alpha; REV-ErbAalpha; REVERBa; THRA1; triiodothyronine receptor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002923 NR1D1; HGNC: NR1D1.
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CL C0002; CC (rec); 2.1.2.3.1.
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SF shows low, but appreciable, binding to T3R [1];
SF shows high sequence similarity to T02747;
SF hinge domain (region D) is very long, over three times longer than that of other nuclear receptor (like e.g. RAR-alpha T00719 and RXR-alpha T01331) [3];
SF this hinge domain is important for transcriptional repression [3];
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FF can function as transcriptional repressor (like other members of the Rev-erb family) which was shown for the homodimer in reporter gene assay using an artificial binding site [3];
FF homodimerization enhanced upon binding to DNA (binding site R11759) [3];
FF blocks transactivation by ROR-alpha1 [3];
FF represses basal transcription an dRAR through naturally occurring response element in CRBPI gene [3];
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IN T02746 Rev-ErbAalpha; human, Homo sapiens.
IN T00838 T3R-alpha; human, Homo sapiens.
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MX M03884 V$REVERBALPHA_Q6.
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BS R40071.
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DR TRANSPATH: MO000026721.
DR UniProtKB: P20393;
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RN [1]; RE0000147.
RX PUBMED: 2539258.
RA Miyajima N., Horiuchi R., Shibuya S.-I., Matsubara K.-I., Toyoshima K., Yamamoto T.
RT Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus
RL Cell 57:31-39 (1989).
RN [2]; RE0002102.
RX PUBMED: 1850510.
RA Laudet V., Begue A., Henry-Duthoit C., Joubel A., Martin P., Stehelin D., Saule S.
RT Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene
RL Nucleic Acids Res. 19:1105-1112 (1991).
RN [3]; RE0010605.
RX PUBMED: 7651396.
RA Harding H. P., Lazar M. A.
RT The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat
RL Mol. Cell. Biol. 15:4791-4802 (1995).
RN [4]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [5]; RE0013667.
RX PUBMED: 1971514.
RA Lazar M. A., Jones K. E., Chin W. W.
RT Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone
RL DNA Cell Biol. 9:77-83 (1990).
RN [6]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
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