AC T02792
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ID T02792
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DT 05.08.1999 (created); mpr.
DT 25.01.2013 (updated); uat.
CO Copyright (C), QIAGEN.
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FA Crx
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SY cone rod homeobox protein.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004498 CRX; HGNC: CRX.
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HO Otx1, Otx2 (human) T02079,T02082.
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CL C0006; homeo; 3.1.3.17.3.
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SF related to Otx1 and Otx2 depending sequence similarity and genomic structure [1];
SF chromosomal location: 19q13.3 [1];
SF mutation can cause an autosomal dominant form of cone-rod dystrophy (adCRD) [1];
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EX brain,,,adult; none; Northern blot; RNA (undefined); [1].
EX heart,,,adult; none; Northern blot; RNA (undefined); [1].
EX human, Homo sapiens,fibroblast,,adult; none; Northern blot; total RNA; [1].
EX kidney (right and left),,,adult; none; Northern blot; RNA (undefined); [1].
EX layer of inner and outer segments of retina,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX liver,,,adult; none; Northern blot; RNA (undefined); [1].
EX lung (right and left),,,adult; none; Northern blot; RNA (undefined); [1].
EX muscles,,,adult; none; Northern blot; RNA (undefined); [1].
EX pancreas,,,adult; none; Northern blot; RNA (undefined); [1].
EX placenta,,,adult; none; Northern blot; RNA (undefined); [1].
EX retina,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
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FF essential for the maintenance of mammalian photoreceptors [1];
FF 2 nucleotides in the PCE-1 DNA binding site R12735 seem to determine RX T05157 versus CRX >T02792> binding specificity: RX prefers CAattag and CRX TGattag [2];
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MX M01436 V$CRX_02.
MX M00623 V$CRX_Q4.
MX M01712 V$CRX_Q4_01.
MX M07352 V$CRX_Q4_02.
MX M08892 V$CRX_Q6.
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BS R30517.
BS R41514.
BS R41516.
BS R30516.
BS R33359.
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DR TRANSPATH: MO000026764.
DR PATHODB: MT010490.
DR PATHODB: MT010491.
DR PATHODB: MT010492.
DR PATHODB: MT010493.
DR PATHODB: MT010494.
DR PATHODB: MT010495.
DR PATHODB: MT010496.
DR PATHODB: MT010497.
DR PATHODB: MT010501.
DR PATHODB: MT010503.
DR PATHODB: MT010504.
DR UniProtKB: O43186;
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RN [1]; RE0014697.
RX PUBMED: 9390563.
RA Freund C. L., Gregory-Evans C. Y., Furukawa T., Papaioannou M., Looser J., Ploder L., Bellingham J., Ng D., Herbrick J.-A., Duncan A., Scherer S. W., Tsui L.-C., Loutradis-Anagnostou A., Jacobson S. G., Cepko C. L., Bhattacharya S. S., McInnes R. R.
RT Cone-Rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
RL Cell 91:543-553 (1997).
RN [2]; RE0017886.
RX PUBMED: 10625658.
RA Kimura A., Singh D., Wawrousek E. F., Kikuchi M., Nakamura M., Shinohara T.
RT Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression.
RL J. Biol. Chem. 275:1152-1160 (2000).
RN [3]; RE0065614.
RX PUBMED: 18854042.
RA Mali R. S., Peng G. H., Zhang X., Dang L., Chen S., Mitton K. P.
RT FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
RL BMC Mol. Biol. 9:87 (2008).
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