TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02792 XX ID T02792 XX DT 05.08.1999 (created); mpr. DT 25.01.2013 (updated); uat. CO Copyright (C), QIAGEN. XX FA Crx XX SY cone rod homeobox protein. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004498 CRX; HGNC: CRX. XX HO Otx1, Otx2 (human) T02079,T02082. XX CL C0006; homeo; XX SF related to Otx1 and Otx2 depending sequence similarity and genomic structure [1]; SF chromosomal location: 19q13.3 [1]; SF mutation can cause an autosomal dominant form of cone-rod dystrophy (adCRD) [1]; XX EX brain,,,adult; none; Northern blot; RNA (undefined); [1]. EX heart,,,adult; none; Northern blot; RNA (undefined); [1]. EX human, Homo sapiens,fibroblast,,adult; none; Northern blot; total RNA; [1]. EX kidney (right and left),,,adult; none; Northern blot; RNA (undefined); [1]. EX layer of inner and outer segments of retina,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1]. EX liver,,,adult; none; Northern blot; RNA (undefined); [1]. EX lung (right and left),,,adult; none; Northern blot; RNA (undefined); [1]. EX muscles,,,adult; none; Northern blot; RNA (undefined); [1]. EX pancreas,,,adult; none; Northern blot; RNA (undefined); [1]. EX placenta,,,adult; none; Northern blot; RNA (undefined); [1]. EX retina,,,adult; detectable; Northern blot; mRNA (poly-A); [1]. XX FF essential for the maintenance of mammalian photoreceptors [1]; FF 2 nucleotides in the PCE-1 DNA binding site R12735 seem to determine RX T05157 versus CRX >T02792> binding specificity: RX prefers CAattag and CRX TGattag [2]; XX MX M01436 V$CRX_02. MX M00623 V$CRX_Q4. MX M01712 V$CRX_Q4_01. MX M07352 V$CRX_Q4_02. MX M08892 V$CRX_Q6. XX BS R30517. BS R41514. BS R41516. BS R30516. BS R33359. XX DR TRANSPATH: MO000026764. DR PATHODB: MT010490. DR PATHODB: MT010491. DR PATHODB: MT010492. DR PATHODB: MT010493. DR PATHODB: MT010494. DR PATHODB: MT010495. DR PATHODB: MT010496. DR PATHODB: MT010497. DR PATHODB: MT010501. DR PATHODB: MT010503. DR PATHODB: MT010504. DR UniProtKB: O43186; XX RN [1]; RE0014697. RX PUBMED: 9390563. RA Freund C. L., Gregory-Evans C. Y., Furukawa T., Papaioannou M., Looser J., Ploder L., Bellingham J., Ng D., Herbrick J.-A., Duncan A., Scherer S. W., Tsui L.-C., Loutradis-Anagnostou A., Jacobson S. G., Cepko C. L., Bhattacharya S. S., McInnes R. R. RT Cone-Rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor RL Cell 91:543-553 (1997). RN [2]; RE0017886. RX PUBMED: 10625658. RA Kimura A., Singh D., Wawrousek E. F., Kikuchi M., Nakamura M., Shinohara T. RT Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression. RL J. Biol. Chem. 275:1152-1160 (2000). RN [3]; RE0065614. RX PUBMED: 18854042. RA Mali R. S., Peng G. H., Zhang X., Dang L., Chen S., Mitton K. P. RT FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. RL BMC Mol. Biol. 9:87 (2008). XX //