AC T02897
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ID T02897
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DT 13.01.2000 (created); sur.
DT 11.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Sox-6-Isoform1
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SY Sox-6; Sox6; Sox6-Isoform1; SRY type HMG box 6; SRY-box containing gene 6.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009657 Sox6.
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CL C0015; HMG; 4.1.1.4.2.1.
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SZ 827 AA; 91.8 kDa (cDNA) (calc.).
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SQ MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLV
SQ STIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTP
SQ ERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGT
SQ PESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQ
SQ QQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPG
SQ DNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHS
SQ YNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDET
SQ TAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDI
SQ LSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEK
SQ ERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGAT
SQ VAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKS
SQ MSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEM
SQ RQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYG
SQ MKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN
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SC translated from EMBL #U32614
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FT 235 686 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 619 689 
SM00398; hmgende2.
FT 620 688 
PF00505; HMG (high mobility group) box.
FT 620 688 
PS50118; HMG_BOX_2.
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SF homology to SOX-5;
SF SOX-5 gene maps to chromosome 6 but SOX-6 maps to chromosome 7 [1];
SF at least four splice variants [2];
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CP developing nervous system; (adult:) testis [1]; inner epithelial layer of the otic vesicle during ear development E9,5 [2] [1] [2].
CN (adult:) lung, liver, kidney, heart, brain.
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FF role in the development of CNS, cartilage and muscle and erythropoiesis [4];
FF transcriptional repressor in silencing epsilon y globin in definitive erythropoiesis [4];
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IN T09093 ipf1; mouse, Mus musculus.
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MX M03888 V$SOX6_Q5.
MX M08899 V$SOX_Q4.
MX M01014 V$SOX_Q6.
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BS R09128.
BS R08516.
BS R19171.
BS R15267.
BS R15273.
BS R19170.
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DR TRANSPATH: MO000026865.
DR EMBL: U32614;
DR UniProtKB: P40645-1;
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RN [1]; RE0012403.
RX PUBMED: 7567444.
RA Connor F., Wright E., Denny P., Koopman P., Ashworth A.
RT The Sry-related HMG box-conrtaining gene Sox6 is expressed in the adult testis and developing nervous system of the mouse
RL Nucleic Acids Res. 23:3365-3372 (1995).
RN [2]; RE0024481.
RX PUBMED: 11504872.
RA Murakami A., Ishida S., Thurlow J., Revest J. M., Dickson C.
RT SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.
RL Nucleic Acids Res. 29:3347-3355 (2001).
RN [3]; RE0048404.
RX PUBMED: 16148004.
RA Iguchi H., Ikeda Y., Okamura M., Tanaka T., Urashima Y., Ohguchi H., Takayasu S., Kojima N., Iwasaki S., Ohashi R., Jiang S., Hasegawa G., Ioka R. X., Magoori K., Sumi K., Maejima T., Uchida A., Naito M., Osborne T. F., Yanagisawa M., Yamamoto T. T., Kodama T., Sakai J.
RT SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.
RL J. Biol. Chem. 280:37669-37680 (2005).
RN [4]; RE0047496.
RX PUBMED: 16462943.
RA Yi Z., Cohen-Barak O., Hagiwara N., Kingsley P. D., Fuchs D. A., Erickson D. T., Epner E. M., Palis J., Brilliant M. H.
RT Sox6 Directly Silences Epsilon Globin Expression in Definitive Erythropoiesis.
RL PLoS Genet. 2:e14 (2006).
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