AC T03371
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ID T03371
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DT 22.05.2000 (created); rio.
CO Copyright (C), QIAGEN.
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FA unc-30
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SY B0564.10.
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OS Caenorhabditis elegans
OC eukaryota; animalia; metazoa; nematoda; secernentea; rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae
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CL C0006; homeo.
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SZ 319 AA; 35.7 kDa (cDNA) (calc.).
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SQ MDDNTATLTAIHQQQQSHNRFSNPLVCVGQLDHHSLLPEHSISSSLAPLTHNPYAFNYSI
SQ PLPPTDITTKLPKLELLSLDVKQEQDDNHLDTSSPTDSTGNGSTNGGKIQKPRRQRTHFT
SQ SHQLTELENWFSRNRYPDMACREEIAVWISLTEPRVRVWFKNRRAKWRKRERNYVIDNGQ
SQ GTTKVTAQSLDPLGSLQNTFPQTLLQSSSSQLDDSAVTSSSFYGYGGAWQQNPYYSRNNQ
SQ TTFNWQIKPQFQTIPMSPTTATSRFSTAANLAPLPTAQAAFSTSATSSNDKLKLMDGLSN
SQ SLSSSLGQPYQPCQYSGPL
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SC translated from EMBL #Z73422
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FT 110 170 
PS50071; HOMEOBOX_2.
FT 112 168 
PS50552; PAX.
FT 112 174 
SM00389; HOX_1.
FT 113 169 
PF00046; Homeobox domain.
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SF two unc-30 mutants (e646 and e165) have mutations within the homeo domain [1];
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CP (stage L1:) dorsal D neurons, preanal ganglion, sensory neurons and interneurons (ASGL, ASGR, RIH, RID), (stage L2:) dorsal and ventral D neurons, preanal ganglion, sensory neurons and interneurons (ASGL, ASGR, RIH, RID) [1].
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FF required for development and functioning of the 19 inhibitory GABAeric type D motor neurons [1];
FF ectopic expression of unc-30 can induce ectopic GABA expression in many cell types [1];
FF Pitx2 T02410 of mouse can rescue unc-30 mutant phenotype [2];
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DR TRANSPATH: MO000027308.
DR EMBL: L37867;
DR EMBL: Z73422;
DR UniProtKB: P52906-2;
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RN [1]; RE0014541.
RX PUBMED: 7997265.
RA Jin Y., Hoskins R., Horvitz H. R.
RT Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein
RL Nature 372:780-783 (1994).
RN [2]; RE0016849.
RX PUBMED: 11517269.
RA Westmoreland J. J., McEwen J., Moore B. A., Jin Y., Condie B. G.
RT Conserved function of Caenorhabditis elegans UNC-30 and mouse Pitx2 in controlling GABAergic neuron differentiation
RL J. Neurosci. 21:6810-6819 (2001).
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