AC T02410
XX
ID T02410
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DT 16.04.1998 (created); ewi.
DT 24.01.2012 (updated); grs.
CO Copyright (C), QIAGEN.
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FA pitx2
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SY Otlx2; Pitx2; Ptx-2; Ptx2; RGS; RIEG.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002666 Pitx2.
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CL C0006; homeo; 3.1.3.19.2.1.
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SZ 271 AA; 30.3 kDa (cDNA) (calc.).
XX
SQ METNCRKLVSACVQLEKDKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQR
SQ NRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQP
SQ YDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSM
SQ VPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRL
SQ KAKQHSSFGYASVQNPASNLSACQYAVDRPV
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SC Swiss-Prot#P97474-3
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FT 37 97 
PS50071; HOMEOBOX_2.
FT 39 95 
PS50552; PAX.
FT 39 101 
SM00389; HOX_1.
FT 40 96 
PF00046; Homeobox domain.
FT 228 248 
PF03826; OAR domain.
FT 233 246 
PS50803; OAR.
XX
EX brain,,,Theiler Stage 22; detectable; RT-PCR; RNA (undefined); [5].
EX brain,,,adult; detectable; RT-PCR; RNA (undefined); [5].
EX eye and related structures (right and left),,,Theiler Stage 21; detectable; RT-PCR; RNA (undefined); [5].
EX heart,,,adult; detectable; RT-PCR; RNA (undefined); [5].
EX kidney (right and left),,,adult; detectable; RT-PCR; RNA (undefined); [5].
EX liver,,,adult; none; RT-PCR; RNA (undefined); [5].
EX lung,,,adult; detectable; RT-PCR; RNA (undefined); [5].
EX mouse, Mus musculus,,,Theiler Stage 10; none; RT-PCR; RNA (undefined); [5].
EX mouse, Mus musculus,,,Theiler Stage 18; detectable; RT-PCR; RNA (undefined); [5].
EX mouse, Mus musculus,,,Theiler Stage 23; detectable; RT-PCR; RNA (undefined); [5].
EX mouse, Mus musculus,,,Theiler Stage 25; detectable; RT-PCR; RNA (undefined); [5].
EX muscles,,,adult; detectable; RT-PCR; RNA (undefined); [5].
EX spleen,,,adult; none; RT-PCR; RNA (undefined); [5].
EX testis (right and left),,,adult; detectable; RT-PCR; RNA (undefined); [5].
XX
FF for expression in teeth, see [4];
FF rescues unc-30 T03371 mutant phenotype of C. elegans [6];
FF regulator of GABAergic differentiation during neural development [6];
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IN T08862 pitx1; mouse, Mus musculus.
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MX M01447 V$PITX2_01.
MX M00482 V$PITX2_Q2.
MX M07056 V$PITX2_Q4.
MX M02114 V$PITX2_Q6.
MX M08895 V$PITX_Q4.
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BS R11015.
BS R11016.
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DR TRANSPATH: MO000026397.
DR EMBL: U70132;
DR EMBL: U80011;
DR EMBL: U80036;
DR UniProtKB: P97474-3;
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RN [1]; RE0006808.
RX PUBMED: 8944018.
RA Semina E. V., Reiter R., Leysens N. J., Alward W. L. M., Small K. W., Datson N. A., Siegle-Bartelt J., Bierke-Nelson D., Bitoun P., Zabel B. U., Carey J. C., Murray J. C.
RT Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome
RL Nat. Genet. 14:392-399 (1996).
RN [2]; RE0006809.
RX PUBMED: 9147650.
RA Gage P. J., Camper S. A.
RT Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation
RL Hum. Mol. Genet. 6:457-464 (1997).
RN [3]; RE0006813.
RX PUBMED: 9299120.
RA Mucchielli M. L., Mitsiadis T. A., Raffo S., Brunet J. F., Proust J. P., Goridis C.
RT Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance
RL Dev. Biol. 189:275-284 (1997).
RN [4]; RE0014825.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/OTLX2.htm
RL Internet : (1996).
RN [5]; RE0016847.
RX PUBMED: 11157981.
RA Hjalt T. A., Amendt B. A., Murray J. C.
RT PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome
RL J. Cell Biol. 152:545-552 (2001).
RN [6]; RE0016849.
RX PUBMED: 11517269.
RA Westmoreland J. J., McEwen J., Moore B. A., Jin Y., Condie B. G.
RT Conserved function of Caenorhabditis elegans UNC-30 and mouse Pitx2 in controlling GABAergic neuron differentiation
RL J. Neurosci. 21:6810-6819 (2001).
XX
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