AC T08862
XX
ID T08862
XX
DT 26.04.2006 (created); kau.
DT 02.03.2012 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA pitx1
XX
SY Bft (Backfoot); P-OTX; P-Otx (Pituarity Otx related factor); Pituarity homeobox 1; Pituitary Homeobox factor 1, Pitx1; Ptx-1; Ptx1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006561 Pitx1.
XX
CL C0006; homeo.
XX
SZ 315 AA; 34.0 kDa (cDNA) (calc.).
XX
SQ MDAFKGGMSLERLPEGLRPPPPPPHDMGPSFHLARAADPREPLENSASESSDADLPDKER
SQ GGEAKGPEDGGAGSAGCGGGAEDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMR
SQ EEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYAAGY
SQ SYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAVPGMPN
SQ SGLNNINNLTGSSLNSAMSPGACPYGTPASPYSVYRDTCNSSLASLALKSKQHSSFGYGG
SQ LQGPASGLNACQYNS
XX
SC translated from EMBL:U54499
XX
FT 88 148 
PS50071; HOMEOBOX_2.
FT 90 146 
PS50552; PAX.
FT 90 152 
SM00389; HOX_1.
FT 91 147 
PF00046; Homeobox domain.
FT 151 281 
Pit-1 interacting domain [1].
FT 281 294 
PS50803; OAR.
XX
IN T08587 c-Jun; mouse, Mus musculus.
IN T10042 Pit-1; Mammalia.
IN T02410 pitx2; mouse, Mus musculus.
IN T25960 pitx2C-beta; mouse, Mus musculus.
IN T04096 Smad3-isoform1; human, Homo sapiens.
IN T18411 Tbx19; mouse, Mus musculus.
XX
MX M01484 V$PITX1_01.
MX M07055 V$PITX1_Q4.
MX M01826 V$PITX1_Q6.
MX M08895 V$PITX_Q4.
XX
BS R32851.
BS R33001.
BS R32849.
BS R32841.
BS R33023.
BS R33024.
BS R22965.
BS R22966.
BS R22967.
BS R04992.
XX
DR TRANSPATH: MO000080631.
DR EMBL: U54499;
DR EMBL: U71206;
DR UniProtKB: P70314;
XX
RN [1]; RE0006817.
RX PUBMED: 8755540.
RA Szeto D. P., Ryan A. K., O Connell S. M., Rosenfeld M. G.
RT P-OTX: A PIT-1-interacting homeodomain factor expressed during anterior pituarity gland development
RL Proc. Natl. Acad. Sci. USA 93:7706-7710 (1996).
RN [2]; RE0047640.
RX PUBMED: 15226417.
RA Jeong K. H., Chin W. W., Kaiser U. B.
RT Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA.
RL Mol. Cell. Biol. 24:6127-6139 (2004).
RN [3]; RE0068203.
RX PUBMED: 18339718.
RA Lamba P., Khivansara V., D'Alessio A. C., Santos M. M., Bernard D. J.
RT Paired-like homeodomain transcription factors 1 and 2 regulate follicle-stimulating hormone beta-subunit transcription through a conserved cis-element.
RL Endocrinology 149:3095-3108 (2008).
RN [4]; RE0068206.
RX PUBMED: 12970370.
RA Maira M., Couture C., Le Martelot G., Pulichino A. M., Bilodeau S., Drouin J.
RT The T-box factor Tpit recruits SRC/p160 co-activators and mediates hormone action.
RL J. Biol. Chem. 278:46523-46532 (2003).
XX
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