AC T03401
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ID T03401
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DT 30.05.2000 (created); rio.
CO Copyright (C), QIAGEN.
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FA unc-37
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SY esg; uncoordinated 37; W02D3.9.
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OS Caenorhabditis elegans
OC eukaryota; animalia; metazoa; nematoda; secernentea; rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae
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HO Groucho (Drosophila), TLE-1 (human).
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SZ 612 AA; 65.6 kDa (cDNA) (calc.).
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SQ MKASYLETLDRIKDEHAEMSKHVNQQRSDIEKVALEKENMNRSYMTYAEVSNTLRSDLRK
SQ AEEINKRLQEFIMQSLAPQLSQDNQANCLAALEAFKTASPRENGNGAPALPPGFPPGAAG
SQ MLGMMPNMPFGMSPAMSQLFNQFASPHVNGGDGAGGSSGGASEAKKAKLEDPDDGELEID
SQ VTNDDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQPLAGLQGLEQMN
SQ FLAGFNPNLLRQASAAGGFNFLNDPHAQARLAAAIGQIGSRPAYSFKIVDGGVPTPTSFP
SQ PDAQKGPGIPTGLKKKMELNHGEVVCAATISRDNSRVYTGGKGCVKIWDVKESDISGATV
SQ VNRPPIASLDCLKENYIRSCKLFEDGNTLLIGGEASTVALWDLTTETKTLDLETDSQACY
SQ ALAMSPDEKLLFACLADGNILIYDIHNKVKVGTLPGHQDGASCLDLSKDGTKLWSGGLDN
SQ SVRCWDLAQRKEVAKHDFASQVFSLGCCPNDEWVAVGMENNYVEVLSTTGKEKYQLTQHE
SQ SCVLSLKFAHSGKFFISTGKDNALNAWRTPYGASLFQLKENSSVLSCDISFDDSLIVTGS
SQ GEKKATLYAVEY
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SC translated from EMBL #U89245
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FT 43 567 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 312 349 
SM00320; WD40_4.
FT 313 349 
PF00400; WD40.
FT 318 495 
PS50294; WD_REPEATS_REGION.
FT 362 402 
SM00320; WD40_4.
FT 364 402 
PF00400; WD40.
FT 405 444 
SM00320; WD40_4.
FT 407 444 
PF00400; WD40.
FT 447 486 
SM00320; WD40_4.
FT 449 486 
PF00400; WD40.
FT 454 495 PS50082; WD_REPEATS_2.
FT 489 527 SM00320; WD40_4.
FT 529 568 SM00320; WD40_4.
FT 531 568 PF00400; WD40.
FT 536 567 PS50082; WD_REPEATS_2.
FT 536 612 PS50294; WD_REPEATS_REGION.
FT 571 609 SM00320; WD40_4.
FT 573 609 PF00400; WD40.
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SF WD repeat 5 is required for unc-37 activity in VA motor neurons [1];
SF highly similar to a family of transcriptional corepressors [1];
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CP ubiquitous [1].
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FF the unc-37-mutant phenotype is similar to unc-4 mutants (animals are unable to crawl backward and tend to coil dorsally when tapped on the head) and also prevents connections of specific VA motor neurons [1];
FF embryonic development probably depends on maternally provided unc-37 [1];
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IN T02991 unc-4; Caenorhabditis elegans.
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DR TRANSPATH: MO000027338.
DR EMBL: AF003141;
DR EMBL: U89245;
DR UniProtKB: O02482;
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RN [1]; RE0014555.
RX PUBMED: 9165118.
RA Pflugrad A., Meir J. Y., Barnes T. M., Miller III D. M.
RT The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans
RL Development 124:1699-1709 (1997).
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//