AC T03490
XX
ID T03490
XX
DT 26.06.2000 (created); sth.
DT 20.08.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Bin1-isoform1
XX
SY bridging integrator protein-1 (BIN1).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G005827 BIN1; HGNC: BIN1.
XX
SZ 591 AA; 64.5 kDa (cDNA) (calc.).
XX
SQ MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR
SQ LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD
SQ QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEK
SQ AAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVN
SQ TFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPP
SQ DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILS
SQ LFEDTFVPEISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLW
SQ EPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGET
SQ AASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQ
SQ LKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTER
XX
SC SPTREMBL #O00499
XX
FT 17 269 
SM00721; BAR.
FT 18 269 
PF03114; BAR domain.
FT 29 276 
PS51021; BAR.
FT 146 560 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 520 591 
PS50002; SH3.
FT 523 590 
SM00326; SH3_2.
FT 523 591 
PF00018; SH3 domain.
XX
SF Myc-interacting protein with features of a tumor suppressor [1];
XX
FF inhibited malignant cell transformation by Myc;
FF associates with the N-terminal transactivation domain of MYC in a manner requiring the integrity of the conserved MYC box regions 1 and 2 (MB1, MB2) [1];
XX
IN T00140 c-Myc-isoform1; human, Homo sapiens.
XX
DR TRANSPATH: MO000027425.
DR EMBL: U68485;
DR UniProtKB: O00499;
XX
RN [1]; RE0014674.
RX PUBMED: 8782822.
RA Sakamuro D., Elliott K. J., Wechsler-Reya R., Prendergast G. C.
RT BIN1 is a novel MYC-interacting protein with features of a tumour suppressor
RL Nat. Genet. 14:69-77 (1996).
XX
//