AC T03503
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ID T03503
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DT 28.06.2000 (created); rio.
DT 28.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA rax
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SY retinal homeobox protein 1; Rx; RX1A.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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GE G092367 rax.S.
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HO Rax (mouse) T03502.
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CL C0006; homeo; 3.1.3.22.1.
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SF embryos with overexpressed rax develop ectopic retinal epithelium and display hyperproliferation in the neuroretina [1];
SF rax represents one of the most anteriorly expressed homeobox genes [2];
SF extended dorsalizing signals elicited by LiCl treatment are able to induce ectopic expression of rax [2];
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CP (early neurula stage 12.5-17:) anterior neural plate, neural ridge, putative forebrain, optic vesicles, (stage 18-27:) optic cups, retina primordia, pineal gland, ventral forebrain (stage 40:) inner neuroblastic layer [2] [1].
CN developing lens [1].
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FF probably important role of the Rx family in the establishment and/or proliferation of retinal progenitor cells [1];
FF may have a role in the genetic control of circadian rhythms [2];
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MX M00623 V$CRX_Q4.
MX M01389 V$RAX_01.
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DR TRANSPATH: MO000027438.
DR UniProtKB: O42201;
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RN [1]; RE0006132.
RX PUBMED: 9177348.
RA Mathers P.H., Ginsberg A., Mahon K. A., Jamrich M.
RT The Rx homeobox gene is essential for vertebrate eye development
RL Nature 387:603-607 (1997).
RN [2]; RE0014720.
RX PUBMED: 9076688.
RA Casarosa S., Andreazzoli M., Simeone A., Barsacchi G.
RT Xrx1, a novel Xenopus homeobox gene expressed during eye and pineal gland development
RL Mech. Dev. 61:187-198 (1997).
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