AC T03502
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ID T03502
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DT 28.06.2000 (created); rio.
DT 30.07.2009 (updated); jag.
CO Copyright (C), QIAGEN.
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FA rax
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SY E130303K03Rik; ey-1; ey1; Mrx; RAX; retina and anterior neural fold homeobox; retina and anterior neural fold homeobox protein; Rx.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006637 Rax.
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HO Rx1 (Xenopus) T03503.
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CL C0006; homeo; 3.1.3.22.1.
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SF chromosomal location: distal region of chromosome 18 [2];
SF OAR domain (initials of Otp, Aristaless and rax) is a conserved region of 14-15 AA C-terminal of the homeo domain [2];
SF embryos carrying a null allele of rax lack anterior brain structures, do not form optic cups and so do not develop eyes [1];
SF 85% amino acid identity between human T05157 and mouse T03502 orthologs [3];
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CP (embryo 7.5 days:) cephalic neural fold, (8.5 days:) forebrain regions, optic placodes, (9.5 days:) optic vesicles/stalk, ventral diencephalon, (10.5 days-newborn:) neuroretina [2] [1]; (10.5-12.5 days:) hypothalamus, posterior pituitary [1] [2] [1].
CN (embryo:) lens, optic tissue or elsewhere, (adult:) retina, heart, lung, kidney, spleen, muscle, thymus, intestine [2], brain, liver [2] [3] [2] [3].
EX brain,,,adult; none; Northern blot; total RNA; [2].
EX central nervous system,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX cornea,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX cornea,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX diencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX diencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX future diencephalon,,,Theiler Stage 14; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX future prosencephalon,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX ganglionic layer of retina,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX ganglionic layer of retina,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX ganglionic layer of retina,,,Theiler Stage 27; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX ganglionic layer of retina,,,neonate (during the first month after birth); none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX headfold,,,Theiler Stage 11; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX heart,,,adult; none; Northern blot; total RNA; [2].
EX inner nuclear layer of retina,,,neonate (during the first month after birth); medium; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX intestine,,,adult; none; Northern blot; total RNA; [2].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [2].
EX lens placode,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens vesicle,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens vesicle,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX liver,,,adult; none; Northern blot; total RNA; [2].
EX lung,,,adult; none; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 9; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX muscles,,,adult; none; Northern blot; total RNA; [2].
EX neural layer of retina,,,Theiler Stage 26; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX neural retinal epithelium,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic cup,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic cup,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic fissure,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic fissure,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic stalk,,,Theiler Stage 14; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic stalk,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic vesicle,,,Theiler Stage 13; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic vesicle,,,Theiler Stage 14; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic vesicle,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic vesicle,,,Theiler Stage 15; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX outer nuclear layer of retina,,,neonate (during the first month after birth); medium; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX retina,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX retina,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX retina,,,Theiler Stage 27; high; Northern blot; total RNA; [2].
EX retina,,,adult; none; Northern blot; total RNA; [2].
EX retina,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX retina,,,neonate (during the first month after birth); medium; Northern blot; total RNA; [2].
EX spleen,,,adult; none; Northern blot; total RNA; [2].
EX thymus,,,adult; none; Northern blot; total RNA; [2].
EX ventral edge of the headfold,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX ventricular layer of diencephalon,,,Theiler Stage 27; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
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FF probably involved in early development of the eye field and proliferation and/or differentiation of retinal cells [2] [1];
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MX M00623 V$CRX_Q4.
MX M01389 V$RAX_01.
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DR TRANSPATH: MO000027437.
DR UniProtKB: O35602;
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RN [1]; RE0006132.
RX PUBMED: 9177348.
RA Mathers P.H., Ginsberg A., Mahon K. A., Jamrich M.
RT The Rx homeobox gene is essential for vertebrate eye development
RL Nature 387:603-607 (1997).
RN [2]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [3]; RE0017886.
RX PUBMED: 10625658.
RA Kimura A., Singh D., Wawrousek E. F., Kikuchi M., Nakamura M., Shinohara T.
RT Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression.
RL J. Biol. Chem. 275:1152-1160 (2000).
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