AC T03940
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ID T03940
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DT 17.10.2000 (created); sth.
DT 17.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Mga
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SY MAD5; MAX gene associated.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006422 Mga.
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CL C0012; bHLH-ZIP; 1.2.6.7.46.5.5.0.2.
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SF Max-interacting protein;
SF contains a Myc-like bHLHZip motif;
SF Mga requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG [1];
SF contains second highly conserved DNA-binding domain and dimerization motif: T-box or T-domain [1];
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FF transcriptional regulator [1];
FF suppresses transcription activation by c-Myc and inhibits Myc-dependent cell transformation;
FF hypothesis: Mga regulates Myc-Max target genes in vivo [1];
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IN T08969 nanog; mouse, Mus musculus.
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MX M05300 V$MGA_04.
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DR TRANSPATH: MO000027850.
DR UniProtKB: A2AWL7;
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RN [1]; RE0015190.
RX PUBMED: 10601024.
RA Hurlin P. J., Steingrimsson E., Copeland N. G., Jenkins N. A., Eisenman R. N.
RT Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif
RL EMBO J. 18:7019-7028 (1999).
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