AC T03978
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ID T03978
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DT 24.10.2000 (created); rio.
DT 07.04.2009 (updated); pum.
CO Copyright (C), QIAGEN.
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FA CART1
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SY cartilage homeoprotein 1; hCart-1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002003 ALX1; HGNC: Alx1.
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CL C0006; homeo; 3.1.3.1.1.
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SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [1];
SF 95% identity at the amino acid level to rat CART1 T03980 [2];
SF binds as a multimer (probably dimer) to a palindrome motif made of two TAAT sequences separated by a spacer of 3-4bp [3];
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CP (adult:) cervical endometrium tissue, (cell lines:) HeLa cervical carcinoma cells [2].
CN (cell lines:) GH3, somatomammotropic line [2].
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FF may play a role in cervix development [2];
FF transcriptional repressor in nonpituitary cells [2];
FF might be a transcriptional modulator with both repression and activation activities [3];
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MX M00416 V$CART1_01.
MX M01362 V$CART1_02.
MX M01453 V$CART1_03.
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DR TRANSPATH: MO000027888.
DR UniProtKB: Q15699;
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RN [1]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [2]; RE0015234.
RX PUBMED: 8756334.
RA Gordon D. F., Wagner J., Atkinson B. L., Chiono M., Berry R., Sikela J., Gutierrez-Hartmann A.
RT Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA
RL DNA Cell Biol. 15:531-541 (1996).
RN [3]; RE0015244.
RX PUBMED: 9753625.
RA Cai R. L.
RT Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites
RL Biochem. Biophys. Res. Commun. 250:305-311 (1998).
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