TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T03978 XX ID T03978 XX DT 24.10.2000 (created); rio. DT 07.04.2009 (updated); pum. CO Copyright (C), QIAGEN. XX FA CART1 XX SY cartilage homeoprotein 1; hCart-1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002003 ALX1; HGNC: Alx1. XX CL C0006; homeo; XX SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [1]; SF 95% identity at the amino acid level to rat CART1 T03980 [2]; SF binds as a multimer (probably dimer) to a palindrome motif made of two TAAT sequences separated by a spacer of 3-4bp [3]; XX CP (adult:) cervical endometrium tissue, (cell lines:) HeLa cervical carcinoma cells [2]. CN (cell lines:) GH3, somatomammotropic line [2]. XX FF may play a role in cervix development [2]; FF transcriptional repressor in nonpituitary cells [2]; FF might be a transcriptional modulator with both repression and activation activities [3]; XX MX M00416 V$CART1_01. MX M01362 V$CART1_02. MX M01453 V$CART1_03. XX DR TRANSPATH: MO000027888. DR UniProtKB: Q15699; XX RN [1]; RE0014693. RX PUBMED: 9096350. RA Furukawa T., Kozak C. A., Cepko C. L. RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997). RN [2]; RE0015234. RX PUBMED: 8756334. RA Gordon D. F., Wagner J., Atkinson B. L., Chiono M., Berry R., Sikela J., Gutierrez-Hartmann A. RT Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA RL DNA Cell Biol. 15:531-541 (1996). RN [3]; RE0015244. RX PUBMED: 9753625. RA Cai R. L. RT Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites RL Biochem. Biophys. Res. Commun. 250:305-311 (1998). XX //