AC T03980
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ID T03980
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DT 24.10.2000 (created); rio.
DT 07.04.2009 (updated); pum.
CO Copyright (C), QIAGEN.
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FA CART1
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SY cartilage homeoprotein 1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002004 Alx1.
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CL C0006; homeo; 3.1.3.1.1.
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SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [1];
SF high degree of sequence identity with the homeo domain of Smox-3 (78%), Al (75%), Pax-3 T00680 (70%), MHox T02966 (67%) and S8 T01483 (65%) [3];
SF 95% identity at the amino acid level to human CART1 T03978 [2];
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CP (embryo 14-18 days:) skeletal tissues, (embryo 14.5-16.5 days:) developing cartilage, ribs, nasal septum, iliac primordium, (newborn:) rib cartilage, (adult:) chondrosarcoma tumor, low in testis, (cell lines:) chondrosarcoma cell line [3].
CN (adult:) skin, liver, spleen, lung, kidney, heart, brain, spinal cord, gastrointestinal system, (cell lines:) skin fibroblasts [3].
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FF may play a role in chondrocyte differentiation [3];
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MX M00416 V$CART1_01.
MX M01362 V$CART1_02.
MX M01453 V$CART1_03.
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DR TRANSPATH: MO000027890.
DR UniProtKB: Q63087;
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RN [1]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [2]; RE0015234.
RX PUBMED: 8756334.
RA Gordon D. F., Wagner J., Atkinson B. L., Chiono M., Berry R., Sikela J., Gutierrez-Hartmann A.
RT Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA
RL DNA Cell Biol. 15:531-541 (1996).
RN [3]; RE0015236.
RX PUBMED: 7690966.
RA Zhao G. Q., Zhou X., Eberspaecher H., Solursh M., de Crombrugghe B.
RT Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes
RL Proc. Natl. Acad. Sci. USA 90:8633-8637 (1993).
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