AC T03995
XX
ID T03995
XX
DT 07.11.2000 (created); dkl.
DT 14.06.2006 (updated); kau.
CO Copyright (C), QIAGEN.
XX
FA SRF-M
XX
SY SRF (440 AA); SRF-M.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002018 Srf.
XX
CL C0014; MADS.
XX
SZ 440 AA; 44.6 kDa (cDNA) (calc.).
XX
SQ MLPSQAGAAAALGRGSALGGNLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGQSRLEREA
SQ AAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGY
SQ GPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVL
SQ LLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEEP
SQ DLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLA
SQ PVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQ
SQ APQQASPSRDSSTDLTQTSSSGTGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSS
SQ SNLTELQVVNLDATHSTKSE
XX
SC Sequence taken from Ref. [1]
XX
FT 137 196 
SM00432; MADS.
FT 137 197 
PS50066; MADS_BOX_2.
FT 143 437 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 145 195 
PF00319; SRF-type transcription factor (DNA-binding a.
XX
SF full length cDNA clone is T00765;
SF exon 5 is missing [1];
SF in alternative splice variant T03996 exons 4 and 5 are missing, in T03997 exons 3, 4 and 5 are missing [1];
SF binding DNA as homodimer [2];
SF heterodimerization with C-terminal truncated SRF [2];
XX
CP Embryo:E9,E10,E13,E14 [1];adult: testis, liver, kidney, lung, uterus, aorta, heart, skeletal muscle [1]; brain, heart [2]; C2C12 un- and differentiated myoblasts, myotubes [1]; rat VSMC [1]; protein level: P19 cells, C2C12 myoblasts [1] [1] [2].
CN adult: liver, kidney, spleen, stomach [2].
XX
FF inhibition of SRE-dependent promoter activity of cardiac alpha-actin promoter, skeletal alpha-actin promoter, SM22 alpha promoter and smooth alpha actin promoter [2];
FF repression of serum-induced activity of c-fos-SRE [2];
XX
MX M00152 V$SRF_01.
MX M01257 V$SRF_02.
MX M00215 V$SRF_C.
MX M07618 V$SRF_Q3.
MX M00810 V$SRF_Q4.
MX M00922 V$SRF_Q5_01.
MX M01007 V$SRF_Q5_02.
MX M00186 V$SRF_Q6.
XX
BS R09532.
XX
DR TRANSPATH: MO000027905.
DR EMBL: AB038376;
XX
RN [1]; RE0015274.
RX PUBMED: 10642500.
RA Kemp P. R., Metcalfe J. C.
RT Four isoforms of serum response factor that increase or inhibit smooth-muscle-specific promoter activity
RL Biochem. J. 345:445-451 (2000).
RN [2]; RE0015300.
RX PUBMED: 10373507.
RA Belaguli N. S., Zhou W., Trinh T. H., Majesky M. W., Schwartz R. J.
RT Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets
RL Mol. Cell. Biol. 19:4582-4591 (1999).
XX
//