AC T04020
XX
ID T04020
XX
DT 23.11.2000 (created); rio.
DT 15.04.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA Gbx2
XX
SY gastrulation and brain specific homeobox protein 2; MMoxA; stimulated with RA 7; Stra7.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002048 Gbx2.
XX
CL C0006; homeo; 3.1.1.11.2.
XX
SF tightly linked to En-1 T02016 [3];
XX
CP (gastrula:) primitive streak, (embryo 11.5-13.5 days:) forebrain [3] [1]; (cell lines:) undiff. ES cells, embryoid bodies [2] [1] [2] [3].
EX brain,,,Theiler Stage 25; high; RNAse protection assay; RNA (undefined); [2].
EX heart,,,adult; none; RNAse protection assay; RNA (undefined); [2].
EX inner cell mass,pluripotent cell,,Theiler Stage 5; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX intestine,,,Theiler Stage 25; low; RNAse protection assay; RNA (undefined); [2].
EX kidney (right and left),,,Theiler Stage 25; none; RNAse protection assay; RNA (undefined); [2].
EX kidney (right and left),,,adult; none; RNAse protection assay; RNA (undefined); [2].
EX limbs,,,Theiler Stage 25; none; RNAse protection assay; RNA (undefined); [2].
EX liver,,,Theiler Stage 25; none; RNAse protection assay; RNA (undefined); [2].
EX liver,,,adult; none; RNAse protection assay; RNA (undefined); [2].
EX lung,,,Theiler Stage 25; none; RNAse protection assay; RNA (undefined); [2].
EX lung,,,adult; none; RNAse protection assay; RNA (undefined); [2].
EX medial septal nucleus,,,adult; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [5].
EX muscles,,,adult; none; RNAse protection assay; RNA (undefined); [2].
EX paraventricular nucleus of thalamus,,,adult; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [5].
EX placenta,,,adult; none; RNAse protection assay; RNA (undefined); [2].
EX skin,,,Theiler Stage 25; none; RNAse protection assay; RNA (undefined); [2].
EX spleen,,,adult; detectable; RNAse protection assay; RNA (undefined); [2].
XX
FF candidate control gene for cell pluripotency and differentiation in the embryo, may play an important role in the developmental fate of pluripotent cells in the early embryo [2];
FF morphogenesis of the mouse inner ear [4];
XX
MX M01382 V$GBX2_01.
XX
BS R67208.
XX
DR TRANSPATH: MO000027929.
DR UniProtKB: P48031;
XX
RN [1]; RE0014515.
RX PUBMED: 1720547.
RA Murtha M. T., Leckman J. F., Ruddle F. H.
RT Detection of homeobox genes in development and evolution
RL Proc. Natl. Acad. Sci. USA 88:10711-10715 (1991).
RN [2]; RE0015346.
RX PUBMED: 9417909.
RA Chapman G., Remiszewski J. L., Webb G. C., Schulz T. C., Bottema C. D., Rathjen P. D.
RT The mouse homeobox gene, Gbx2: genomic organization and expression in pluripotent cells in vitro and in vivo
RL Genomics 46:223-233 (1997).
RN [3]; RE0015359.
RA Frohman M. A., Dickinson M. E., Hogan B. L. M., Martin G. R.
RT Mapping of Gbx-1 to mouse chromosome 5 and Gbx-2 to mouse chromosome 1
RL Mouse Genome 91:323-325 (1993).
RN [4]; RE0035288.
RX PUBMED: 15829521.
RA Lin Z., Cantos R., Patente M., Wu D. K.
RT Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling.
RL Development 132:2309-2318 (2005).
RN [5]; RE0035283.
RX PUBMED: 11801365.
RA Asbreuk C. H., van Schaick H. S., Cox J. J., Kromkamp M., Smidt M. P., Burbach J. P.
RT The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system.
RL Neuroscience 109:287-298 (2002).
XX
//