AC T02016
XX
ID T02016
XX
DT 16.12.1996 (created); ewi.
DT 24.04.2008 (updated); grs.
CO Copyright (C), QIAGEN.
XX
FA En-1
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SY Engrailed 1; Mo-en.1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006023 En1.
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HO En (Drosophila) T00253.
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CL C0006; homeo; 3.1.2.7.1.
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SF tightly linked to Gbx-2 T04020 [9];
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CP embryo: highest levels in posterior brain, low in carcass, limbs, placenta, spinal cord, very low in yolk sac [2] [3].
CN anterior brain, face, viscera [2] [3].
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FF required for normal development of mid- and hindbrain, mutations cause lethal brain deletions [8];
FF despite a different expression pattern, En-2 may substitute for En1 when placed under control of the En-1 promoter [6];
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IN T00682 Pax-6; zebra fish, Brachydanio rerio.
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MX M00396 V$EN1_01.
MX M01365 V$EN1_02.
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BS R15135.
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DR TRANSPATH: MO000026096.
DR UniProtKB: P09065;
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RN [1]; RE0003871.
RX PUBMED: 8096059.
RA Catron K. M., Iller N., Abate C.
RT Nucleotides flanking a conserved TAAT core dictate the DNA binding specifity of three murine homeodomain proteins
RL Mol. Cell. Biol. 13:2354-2365 (1993).
RN [2]; RE0005044.
RX PUBMED: 2892757.
RA Joyner A. L., Martin G. R.
RT En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis
RL Genes Dev. 1:29-38 (1987).
RN [3]; RE0005045.
RX PUBMED: 1363401.
RA Logan C., Hanks M. C., Noble-Topham S., Nallainathan D., Provart N. J., Joyner A. L.
RT Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions
RL Dev. Genet. 13:345-358 (1992).
RN [4]; RE0005046.
RX PUBMED: 2416459.
RA Joyner L. A., Kornberg T., Coleman K. G., Cox D. R., Martin G. R.
RT Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene
RL Cell 43:29-37 (1985).
RN [5]; RE0005047.
RX PUBMED: 1980115.
RA Holland P. W. H., Williams N. A.
RT Conservation of engrailed-like homeobox sequences during vertebrate evolution
RL FEBS Lett. 277:250-252 (1990).
RN [6]; RE0005048.
RX PUBMED: 7624797.
RA Hanks M., Wurst W., Anson-Cartwright L., Auerbach A. B., Joyner A. L.
RT Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2
RL Science 269:679-682 (1995).
RN [7]; RE0005050.
RX PUBMED: 1534034.
RA McMahon A. P., Joyner A. L., Bradley A., McMahon J. A.
RT The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
RL Cell 69:581-595 (1992).
RN [8]; RE0005498.
RX PUBMED: 7925010.
RA Wurst W., Auerbach A. B., Joyner A. L.
RT Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum
RL Development 120:2065-2075 (1994).
RN [9]; RE0015359.
RA Frohman M. A., Dickinson M. E., Hogan B. L. M., Martin G. R.
RT Mapping of Gbx-1 to mouse chromosome 5 and Gbx-2 to mouse chromosome 1
RL Mouse Genome 91:323-325 (1993).
RN [10]; RE0047970.
RX PUBMED: 11069920.
RA Mikkola I., Bruun J. A., Holm T., Johansen T.
RT Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.
RL J. Biol. Chem. 276:4109-4118 (2001).
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//