AC T04188
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ID T04188
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DT 17.01.2001 (created); rio.
DT 05.05.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA lhx6.1-isoform2
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SY LIM homeobox protein 6.1b.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004547 Lhx6.
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CL C0025; LIM-homeo.
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SZ 348 AA; 38.3 kDa (cDNA) (calc.).
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SQ MAQPGSGCKATTRCLEGTTPPAMAQSDAEALAGALDKDEGRASPCTPSTPSVCSPPSAAS
SQ SVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIYCK
SQ MDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVL
SQ CRIHYDTMIENLKKAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQ
SQ DNNPDAQTLQKLADMTGFSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPTRLPSALSDD
SQ IHYSPFSSPERARMVTLHGYIESHPFSVLTLPALAHLSMGTTQLPLSR
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SC translated from EMBL #AB031039
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FT 68 128 
PS50023; LIM_DOMAIN_2.
FT 69 122 
SM00132; lim_4.
FT 70 128 
PF00412; LIM domain.
FT 129 191 
PS50023; LIM_DOMAIN_2.
FT 130 184 
SM00132; lim_4.
FT 131 190 
PF00412; LIM domain.
FT 217 277 
PS50071; HOMEOBOX_2.
FT 219 281 
SM00389; HOX_1.
FT 220 276 
PF00046; Homeobox domain.
FT 220 276 
PS50558; LIM_HOMEODOMAIN.
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SF two splice variants with different expression rates: Lhx6.1a T04187 expression peaks in P2.0 brain and remains high in adulthood whereas lhx6.1-isoform2 expression peaks from E18.5-P2.0 and then decreased at P14.0 through adulthood [1];
SF 95% homology to human LHX6.1b T04190 [1];
SF physical interaction with CLIM2 T02252, both tandem LIM domains are necessary for binding [1];
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EX brain,,,Theiler Stage 27; detectable; RT-PCR; total RNA; [1].
EX brain,,,Theiler Stage 28; detectable; RT-PCR; total RNA; [1].
EX brain,,,adult; low; RT-PCR; total RNA; [1].
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FF may play a role in CNS and molar tooth development [1];
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IN T02252 CLIM2; mouse, Mus musculus.
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MX M01314 V$LHX61_01.
MX M01422 V$LHX61_02.
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DR TRANSPATH: MO000028081.
DR EMBL: AB031039;
DR UniProtKB: Q9R1R0-2;
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RN [1]; RE0015585.
RX PUBMED: 10393337.
RA Kimura N., Ueno M., Nakashima K., Taga T.
RT A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains
RL J. Biochem. 126:180-187 (1999).
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