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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T04188 XX ID T04188 XX DT 17.01.2001 (created); rio. DT 05.05.2009 (updated); mkl. CO Copyright (C), QIAGEN. XX FA lhx6.1-isoform2 XX SY LIM homeobox protein 6.1b. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G004547 Lhx6. XX CL C0025; LIM-homeo. XX SZ 348 AA; 38.3 kDa (cDNA) (calc.). XX SQ MAQPGSGCKATTRCLEGTTPPAMAQSDAEALAGALDKDEGRASPCTPSTPSVCSPPSAAS SQ SVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIYCK SQ MDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVL SQ CRIHYDTMIENLKKAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQ SQ DNNPDAQTLQKLADMTGFSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPTRLPSALSDD SQ IHYSPFSSPERARMVTLHGYIESHPFSVLTLPALAHLSMGTTQLPLSR XX SC translated from EMBL #AB031039 XX FT 68 128 PS50023; LIM_DOMAIN_2. FT 69 122 SM00132; lim_4. FT 70 128 PF00412; LIM domain. FT 129 191 PS50023; LIM_DOMAIN_2. FT 130 184 SM00132; lim_4. FT 131 190 PF00412; LIM domain. FT 217 277 PS50071; HOMEOBOX_2. FT 219 281 SM00389; HOX_1. FT 220 276 PF00046; Homeobox domain. FT 220 276 PS50558; LIM_HOMEODOMAIN. XX SF two splice variants with different expression rates: Lhx6.1a T04187 expression peaks in P2.0 brain and remains high in adulthood whereas lhx6.1-isoform2 expression peaks from E18.5-P2.0 and then decreased at P14.0 through adulthood [1]; SF 95% homology to human LHX6.1b T04190 [1]; SF physical interaction with CLIM2 T02252, both tandem LIM domains are necessary for binding [1]; XX EX brain,,,Theiler Stage 27; detectable; RT-PCR; total RNA; [1]. EX brain,,,Theiler Stage 28; detectable; RT-PCR; total RNA; [1]. EX brain,,,adult; low; RT-PCR; total RNA; [1]. XX FF may play a role in CNS and molar tooth development [1]; XX IN T02252 CLIM2; mouse, Mus musculus. XX MX M01314 V$LHX61_01. MX M01422 V$LHX61_02. XX DR TRANSPATH: MO000028081. DR EMBL: AB031039; DR UniProtKB: Q9R1R0-2; XX RN [1]; RE0015585. RX PUBMED: 10393337. RA Kimura N., Ueno M., Nakashima K., Taga T. RT A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains RL J. Biochem. 126:180-187 (1999). XX //