AC T04347
XX
ID T04347
XX
DT 22.02.2001 (created); rio.
DT 20.11.2007 (updated); man.
CO Copyright (C), QIAGEN.
XX
FA Tbx5
XX
SY connexin 40; T-box protein 5.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006793 Tbx5.
XX
CL C0044; T-box; 6.5.4.0.4.
XX
SF for detailed expression pattern in the forelimb buds see reference [2];
SF 96% and 88% identity to human T04345 T04346 and chicken Tbx5 T04348 [1];
XX
CP (E8.0:) cardiac crescent, (E8.25:) post. heart, prosp. sinus venosa and atria, (E8.5-9.0:) left ventricle, (E9.5-11.5:) eye, forelimbs, heart, (E13.5:) left ventricle/septum, trabeculae, atrial septa, AV valves, superior vena cavae [2] [1]; both atria and left ventricle on mouse embryo 13.5 dpc [3] [1] [2] [3].
XX
FF involved in limb morphogenesis [2];
FF may be involved in fore-/hindlimb identity [2];
FF involved in heart development especially cardiac septation and left chamber specification [1];
XX
IN T01675 CSX; mouse, Mus musculus.
XX
MX M08900 V$TBX2RELATED_Q6.
MX M01019 V$TBX5_01.
MX M01020 V$TBX5_02.
MX M03856 V$TBX5_Q2.
MX M01044 V$TBX5_Q5.
XX
DR TRANSPATH: MO000028205.
DR UniProtKB: P70326;
XX
RN [1]; RE0015791.
RX PUBMED: 10373308.
RA Bruneau B. G., Logan M., Davis N., Levi T., Tabin C. J., Seidman J. G., Seidman C. E.
RT Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome
RL Dev. Biol. 211:100-108 (1999).
RN [2]; RE0015803.
RX PUBMED: 8798150.
RA Gibson-Brown J. J., Agulnik S. I., Chapman D. L., Alexiou M., Garvey N., Silver L. M., Papaioannou V. E.
RT Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
RL Mech. Dev. 56:93-101 (1996).
RN [3]; RE0024959.
RX PUBMED: 11555635.
RA Ghosh T. K., Packham E. A., Bonser A. J., Robinson T. E., Cross S. J., Brook J. D.
RT Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome.
RL Hum. Mol. Genet. 10:1983-1994 (2001).
XX
//