AC T04445
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ID T04445
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DT 23.04.2001 (created); rio.
DT 03.01.2012 (updated); hna.
CO Copyright (C), QIAGEN.
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FA Nkx5-2
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SY H6 homeobox 2; HMX2; Nkx-5.2; NKX5-2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002450 Hmx2.
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CL C0053; NK-2/Nkx.
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SZ 286 AA; 31.2 kDa (cDNA) (calc.).
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SQ LGRSWFPPISYEPRMAARKMWGRDVRRPVASPASPSSPSWAGALRGTAGARRVASQETQP
SQ VCVLGGGGAGEGWKAPACFCPDPHGPKEPSPKHHTPIPFPCLGTPKGSGGAGPAASERTP
SQ FLSPSHPDFKEEKERLLPAGSPSPGPERPRDGGAERQTGAAKKKTRTVFSRSQVYQLEST
SQ FDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVG
SQ MPLVFRDSSLLRVPVPRSLAFPAPLYYPSSNLSALPLYNLYNKLDY
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SC translated from EMBL #S80989
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FT 160 220 
PS50071; HOMEOBOX_2.
FT 162 224 
SM00389; HOX_1.
FT 163 219 
PF00046; Homeobox domain.
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SF 92% amino acid identity to the homeo domain of Hmx3 T04446 [3];
SF Hmx2 and Hmx3 T04446 are clustered on chromosome 7 [3];
SF Hmx2 and Hmx3 T04446 have overlapping spatial expression patterns but the onset of Hmx3 transcription begins much earlier [1];
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CP (adult:) uterus [2].
CN (E14.5:) thalamus [1].
EX dorsal premammillary nucleus,,,Theiler Stage 26; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX dorsomedial nucleus of dorsal hypothalamus,,,Theiler Stage 26; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mammillary area,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mesencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX myelencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX myelencephalon,,,Theiler Stage 26; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX neural crest of otocyst,,,Theiler Stage 17; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX neural crest of otocyst,,,Theiler Stage 19; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX pons,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX preoptic area,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX preoptic area,,,Theiler Stage 26; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX semicircular canals,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX subthalamus,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
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FF probably involved in cell type specification of neuronal cells [1];
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MX M01315 V$NKX52_01.
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DR TRANSPATH: MO000028295.
DR EMBL: S80989;
DR UniProtKB: P43687;
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RN [1]; RE0016066.
RX PUBMED: 8541222.
RA Rinkwitz-Brandt S., Justus M., Oldenettel I., Arnold H. H., Bober E.
RT Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development
RL Mech. Dev. 52:371-381 (1995).
RN [2]; RE0016068.
RX PUBMED: 9435283.
RA Wang W., Van De Water T., Lufkin T.
RT Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
RL Development 125:621-634 (1998).
RN [3]; RE0016077.
RX PUBMED: 7510254.
RA Bober E., Baum C., Braun T., Arnold H. H.
RT A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development
RL Dev. Biol. 162:288-303 (1994).
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