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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T04446 XX ID T04446 XX DT 23.04.2001 (created); rio. DT 30.05.2013 (updated); mkl. CO Copyright (C), QIAGEN. XX FA Nkx5-1 XX SY H6 homeobox 3; HMX3; Nkx-5.1; NKX5-1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002451 Hmx3. XX CL C0053; NK-2/Nkx. XX SF 92% amino acid identity to the homeo domain of Hmx2 T04445 [3]; SF Hmx3 and Hmx2 T04445 are clustered on chromosome 7 [3]; SF Hmx3 and Hmx2 T04445 have overlapping spatial expression patterns but the onset of Hmx3 transcription begins much earlier [1]; SF represents an early and probably the earliest marker for inner ear development [1]; SF Hmx3 -/- mice have a a diminished postnatal viability, show circling behavior, inner ear defects and reproductive defects (perturbed embryo implantation) and altered Wnt expression [2]; SF glutamine residue at position 50 (Gln50) of the homeo domain is responsible for binding a CAAG core instead of the common TAAT core [4]; SF a 3' flanking TG dinucleotide contributes to an optimal DNA binding [4]; SF Titf1 T00859 and Nkx2-5 T01675 (both with Gln50) have the same CAAGTG binding consensus [4]; XX CP uterus [2]; vestibular structures throughout inner ear development [5] [2] [5]. EX brain,,,Theiler Stage 17; medium; RNAse protection assay; RNA (undefined); [3]. EX brain,,,Theiler Stage 21; very high; RNAse protection assay; RNA (undefined); [3]. EX brain,,,Theiler Stage 24; high; RNAse protection assay; RNA (undefined); [3]. EX brain,,,Theiler Stage 26; medium; RNAse protection assay; RNA (undefined); [3]. EX brain,,,Theiler Stage 28; medium; RNAse protection assay; RNA (undefined); [3]. EX brain,,,adult; none; RNAse protection assay; RNA (undefined); [3]. EX cochlea,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX diencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX dorsal root ganglion,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX dorsal root ganglion,,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX ear,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX eye and related structures (right and left),,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX facio-acoustic complex [VII VIII],,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX first pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX fourth pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX head mesenchyme,,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX hypothalamus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX hypothalamus,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX internal ear,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX intramural ganglia of stomach,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX intramural ganglia of the oesophagus,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX mammillary area,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX mammillary area,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX mesencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX mesencephalon,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX mesencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX mesencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX mesencephalon,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX mouse, Mus musculus,,,Theiler Stage 12; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX myelencephalon,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX myelencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX myelencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX neural crest of otocyst,,,Theiler Stage 14; low; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX neural crest of otocyst,,,Theiler Stage 15; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX neural crest of otocyst,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX neural crest of otocyst,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX neural crest of otocyst,,,Theiler Stage 18; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX neural crest of otocyst,,,Theiler Stage 19; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX neural retinal epithelium,,,Theiler Stage 19; low; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX neural tube,,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX optic cup,,,Theiler Stage 17; low; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX optic cup,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX otic placode,,,Theiler Stage 13; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX pharyngeal arches,,,Theiler Stage 13; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX pharyngeal arches,,,Theiler Stage 18; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX pharyngeal cleft of first pharyngeal arch,,,Theiler Stage 14; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX pons,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX pons,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX pons,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX pons,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX preoptic area,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX preoptic area,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1]. EX second pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX spinal cord,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX subthalamus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX subthalamus,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX third pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX tongue,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX tongue,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX trigeminal ganglion [V],,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX trigeminal ganglion [V],,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. EX wall of atrium,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3]. XX FF probably involved in cell type specification of neuronal cells [1] [3]; FF involved in development of the inner ear [3] [5]; FF important role in vestibular sensory organ development and maternal reproduction [2]; XX MX M00433 V$HMX1_01. MX M01413 V$HMX3_02. XX DR TRANSPATH: MO000028296. DR UniProtKB: P42581; XX RN [1]; RE0016066. RX PUBMED: 8541222. RA Rinkwitz-Brandt S., Justus M., Oldenettel I., Arnold H. H., Bober E. RT Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development RL Mech. Dev. 52:371-381 (1995). RN [2]; RE0016068. RX PUBMED: 9435283. RA Wang W., Van De Water T., Lufkin T. RT Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene RL Development 125:621-634 (1998). RN [3]; RE0016077. RX PUBMED: 7510254. RA Bober E., Baum C., Braun T., Arnold H. H. RT A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development RL Dev. Biol. 162:288-303 (1994). RN [4]; RE0016078. RX PUBMED: 10206974. RA Amendt B. A., Sutherland L. B., Russo A. F. RT Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site RL J. Biol. Chem. 274:11635-11642 (1999). RN [5]; RE0024314. RX PUBMED: 9389661. RA Hadrys T., Braun T., Rinkwitz-Brandt S., Arnold H. H., Bober E. RT Nkx5-1 controls semicircular canal formation in the mouse inner ear. RL Development 125:33-39 (1998). XX //