AC T04446
XX
ID T04446
XX
DT 23.04.2001 (created); rio.
DT 30.05.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Nkx5-1
XX
SY H6 homeobox 3; HMX3; Nkx-5.1; NKX5-1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002451 Hmx3.
XX
CL C0053; NK-2/Nkx.
XX
SF 92% amino acid identity to the homeo domain of Hmx2 T04445 [3];
SF Hmx3 and Hmx2 T04445 are clustered on chromosome 7 [3];
SF Hmx3 and Hmx2 T04445 have overlapping spatial expression patterns but the onset of Hmx3 transcription begins much earlier [1];
SF represents an early and probably the earliest marker for inner ear development [1];
SF Hmx3 -/- mice have a a diminished postnatal viability, show circling behavior, inner ear defects and reproductive defects (perturbed embryo implantation) and altered Wnt expression [2];
SF glutamine residue at position 50 (Gln50) of the homeo domain is responsible for binding a CAAG core instead of the common TAAT core [4];
SF a 3' flanking TG dinucleotide contributes to an optimal DNA binding [4];
SF Titf1 T00859 and Nkx2-5 T01675 (both with Gln50) have the same CAAGTG binding consensus [4];
XX
CP uterus [2]; vestibular structures throughout inner ear development [5] [2] [5].
EX brain,,,Theiler Stage 17; medium; RNAse protection assay; RNA (undefined); [3].
EX brain,,,Theiler Stage 21; very high; RNAse protection assay; RNA (undefined); [3].
EX brain,,,Theiler Stage 24; high; RNAse protection assay; RNA (undefined); [3].
EX brain,,,Theiler Stage 26; medium; RNAse protection assay; RNA (undefined); [3].
EX brain,,,Theiler Stage 28; medium; RNAse protection assay; RNA (undefined); [3].
EX brain,,,adult; none; RNAse protection assay; RNA (undefined); [3].
EX cochlea,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX diencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX dorsal root ganglion,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX dorsal root ganglion,,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX ear,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX eye and related structures (right and left),,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX facio-acoustic complex [VII VIII],,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX first pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX fourth pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX head mesenchyme,,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX hypothalamus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX hypothalamus,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX internal ear,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX intramural ganglia of stomach,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX intramural ganglia of the oesophagus,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX mammillary area,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mammillary area,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mesencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX mesencephalon,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX mesencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mesencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX mesencephalon,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 12; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX myelencephalon,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX myelencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX myelencephalon,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX neural crest of otocyst,,,Theiler Stage 14; low; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX neural crest of otocyst,,,Theiler Stage 15; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX neural crest of otocyst,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX neural crest of otocyst,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX neural crest of otocyst,,,Theiler Stage 18; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX neural crest of otocyst,,,Theiler Stage 19; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX neural retinal epithelium,,,Theiler Stage 19; low; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX neural tube,,,Theiler Stage 19; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic cup,,,Theiler Stage 17; low; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic cup,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX otic placode,,,Theiler Stage 13; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX pharyngeal arches,,,Theiler Stage 13; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX pharyngeal arches,,,Theiler Stage 18; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX pharyngeal cleft of first pharyngeal arch,,,Theiler Stage 14; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX pons,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pons,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX pons,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pons,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX preoptic area,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX preoptic area,,,Theiler Stage 24; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX second pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX spinal cord,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX subthalamus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX subthalamus,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX third pharyngeal arch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX tongue,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX tongue,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX trigeminal ganglion [V],,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX trigeminal ganglion [V],,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX wall of atrium,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
XX
FF probably involved in cell type specification of neuronal cells [1] [3];
FF involved in development of the inner ear [3] [5];
FF important role in vestibular sensory organ development and maternal reproduction [2];
XX
MX M00433 V$HMX1_01.
MX M01413 V$HMX3_02.
XX
DR TRANSPATH: MO000028296.
DR UniProtKB: P42581;
XX
RN [1]; RE0016066.
RX PUBMED: 8541222.
RA Rinkwitz-Brandt S., Justus M., Oldenettel I., Arnold H. H., Bober E.
RT Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development
RL Mech. Dev. 52:371-381 (1995).
RN [2]; RE0016068.
RX PUBMED: 9435283.
RA Wang W., Van De Water T., Lufkin T.
RT Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
RL Development 125:621-634 (1998).
RN [3]; RE0016077.
RX PUBMED: 7510254.
RA Bober E., Baum C., Braun T., Arnold H. H.
RT A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development
RL Dev. Biol. 162:288-303 (1994).
RN [4]; RE0016078.
RX PUBMED: 10206974.
RA Amendt B. A., Sutherland L. B., Russo A. F.
RT Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site
RL J. Biol. Chem. 274:11635-11642 (1999).
RN [5]; RE0024314.
RX PUBMED: 9389661.
RA Hadrys T., Braun T., Rinkwitz-Brandt S., Arnold H. H., Bober E.
RT Nkx5-1 controls semicircular canal formation in the mouse inner ear.
RL Development 125:33-39 (1998).
XX
//